Epidemiology of seasonal coronaviruses: establishing the context for the emergence of coronavirus disease 2019

Nickbakhsh, S. , Ho, A. , Marques, D. F.P., McMenamin, J., Gunson, R. N. and Murcia, P. R. (2020) Epidemiology of seasonal coronaviruses: establishing the context for the emergence of coronavirus disease 2019. Journal of Infectious Diseases, 222(1), pp. 17-25. (doi: 10.1093/infdis/jiaa185) (PMID:32296837) (PMCID:PMC7184404)

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Abstract

Public health preparedness for coronavirus (CoV) disease 2019 (COVID-19) is challenging in the absence of setting-specific epidemiological data. Here we describe the epidemiology of seasonal CoVs (sCoVs) and other cocirculating viruses in the West of Scotland, United Kingdom. We analyzed routine diagnostic data for >70 000 episodes of respiratory illness tested molecularly for multiple respiratory viruses between 2005 and 2017. Statistical associations with patient age and sex differed between CoV-229E, CoV-OC43, and CoV-NL63. Furthermore, the timing and magnitude of sCoV outbreaks did not occur concurrently, and coinfections were not reported. With respect to other cocirculating respiratory viruses, we found evidence of positive, rather than negative, interactions with sCoVs. These findings highlight the importance of considering cocirculating viruses in the differential diagnosis of COVID-19. Further work is needed to establish the occurrence/degree of cross-protective immunity conferred across sCoVs and with COVID-19, as well as the role of viral coinfection in COVID-19 disease severity.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMenamin, Dr Jim and Nickbakhsh, Dr Sema and Gunson, Dr Rory and Murcia, Dr Pablo and Ho, Dr Antonia
Authors: Nickbakhsh, S., Ho, A., Marques, D. F.P., McMenamin, J., Gunson, R. N., and Murcia, P. R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Infectious Diseases
Publisher:Oxford University Press for the Infectious Diseases Society of America
ISSN:0022-1899
ISSN (Online):1537-6613
Published Online:14 April 2020
Copyright Holders:Copyright © The Author(s) 2020
First Published:First published in Journal of Infectious Diseases 222(1):17-25
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
172630Quinquennial Core FundsMassimo PalmariniMedical Research Council (MRC)MC_UU_12014/9III-MRC-GU CVR Support Services