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Thermodynamic analysis of biomolecular interactions

Cooper, A. (1999) Thermodynamic analysis of biomolecular interactions. Current Opinion in Chemical Biology, 3 (5). pp. 557-563. ISSN 1367-5931 (doi:10.1016/S1367-5931(99)00008-3)

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Publisher's URL: http://dx.doi.org/10.1016/S1367-5931(99)00008-3

Abstract

Direct measurement of the thermodynamics of biomolecular interactions is now relatively easy. Interpretation of these thermodynamics in simple molecular terms is not. Recent work shows how the multiplicity of weak noncovalent interactions, and the inevitable enthalpy/entropy compensation that these interactions engender, lead to difficulties in teasing out the different components.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cooper, Prof Alan
Authors: Cooper, A.
Subjects:Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH345 Biochemistry
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Current Opinion in Chemical Biology
Publisher:Elsevier
ISSN:1367-5931

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