Wolbachia strain wAu efficiently blocks arbovirus transmission in Aedes albopictus

Mancini, M. V., Herd, C. S., Ant, T. H., Murdochy, S. M. and Sinkins, S. (2020) Wolbachia strain wAu efficiently blocks arbovirus transmission in Aedes albopictus. PLoS Neglected Tropical Diseases, 14(3), e0007926. (doi: 10.1371/journal.pntd.0007926) (PMID:32155143) (PMCID:PMC7083328)

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Abstract

The global incidence of arboviral diseases transmitted by Aedes mosquitoes, including dengue, chikungunya, yellow fever, and Zika, has increased dramatically in recent decades. The release of Aedes aegypti carrying the maternally inherited symbiont Wolbachia as an intervention to control arboviruses is being trialled in several countries. However, these efforts are compromised in many endemic regions due to the co-localization of the secondary vector Aedes albopictus, the Asian tiger mosquito. Ae. albopictus has an expanding global distribution following incursions into a number of new territories. To date, only the wMel and wPip strains of Wolbachia have been reported to be transferred into and characterized in this vector. A Wolbachia strain naturally infecting Drosophila simulans, wAu, was selected for transfer into a Malaysian Ae. albopictus line to create a novel triple-strain infection. The newly generated line showed self-compatibility, moderate fitness cost and complete resistance to Zika and dengue infections.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sinkins, Professor Steven
Creator Roles:
Sinkins, S.Conceptualization, Funding acquisition, Supervision, Writing – original draft
Authors: Mancini, M. V., Herd, C. S., Ant, T. H., Murdochy, S. M., and Sinkins, S.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:PLoS Neglected Tropical Diseases
Publisher:Public Library of Science
ISSN:1935-2727
ISSN (Online):1935-2735
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in PLoS Neglected Tropical Diseases 14(3):e0007926
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
174018Wolbachia-based control of virus transmission by the mosquito Aedes albopictusSteven SinkinsWellcome Trust (WELLCOTR)108508/Z/15/ZIII-MRC-GU Centre for Virus Research
173477Wolbachia-mediated arbovirus inhibition in mosquitoesSteven SinkinsWellcome Trust (WELLCOTR)202888/Z/16/ZIII-MRC-GU Centre for Virus Research