Schedin, P., O'Brien, J., Rudolph, M., Stein, T. and Borges, V. (2007) Microenvironment of the involuting mammary gland mediates mammary cancer progression. Journal of Mammary Gland Biology and Neoplasia, 12(1), pp. 71-82. (doi: 10.1007/s10911-007-9039-3) (PMID:17318269)
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Abstract
Breast cancer diagnosed after a completed pregnancy has higher metastatic potential and therefore a much poorer prognosis. We hypothesize that following pregnancy the process of mammary gland involution, which returns the gland to its pre-pregnant state, co-opts some of the programs of wound healing. The pro-inflammatory milieu that results, while physiologically normal, promotes tumor progression. In this review, the similarities between mammary gland involution after cessation of milk-production and pathological tissue remodeling are discussed in light of emerging data demonstrating a role for pathological tissue remodeling in cancer.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Stein, Dr Torsten |
| Authors: | Schedin, P., O'Brien, J., Rudolph, M., Stein, T., and Borges, V. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Journal of Mammary Gland Biology and Neoplasia |
| Publisher: | Springer |
| ISSN: | 1083-3021 |
| ISSN (Online): | 1573-7039 |
| Published Online: | 21 February 2007 |
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