Inflammation and premature ageing in chronic kidney disease

Ebert, T., Pawelzik, S.-C., Witasp, A., Arefin, S., Hobson, S., Kublickiene, K., Shiels, P. G. , Bäck, M. and Stenvinkel, P. (2020) Inflammation and premature ageing in chronic kidney disease. Toxins, 12(4), 227. (doi: 10.3390/toxins12040227) (PMID:32260373)

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Abstract

Persistent low-grade inflammation and premature ageing are hallmarks of the uremic phenotype and contribute to impaired health status, reduced quality of life, and premature mortality in chronic kidney disease (CKD). Because there is a huge global burden of disease due to CKD, treatment strategies targeting inflammation and premature ageing in CKD are of particular interest. Several distinct features of the uremic phenotype may represent potential treatment options to attenuate the risk of progression and poor outcome in CKD. The nuclear factor erythroid 2-related factor 2 (NRF2)−kelch-like erythroid cell-derived protein with CNC homology [ECH]-associated protein 1 (KEAP1) signaling pathway, the endocrine phosphate-fibroblast growth factor-23−klotho axis, increased cellular senescence, and impaired mitochondrial biogenesis are currently the most promising candidates, and different pharmaceutical compounds are already under evaluation. If studies in humans show beneficial effects, carefully phenotyped patients with CKD can benefit from them.

Item Type:Articles
Additional Information:Funding: T.E. was supported by a Novo Nordisk postdoctoral fellowship run in partnership with Karolinska Institutet, Stockholm, Sweden. This work was further supported by the Swedish Heart and Lung Foundation (no. 20180571 and 20160384), King Gustaf V and Queen Victoria Freemason Foundation, Professor Nanna Svartz Foundation, the Stockholm County Council (20170365), Njurfonden (Swedish Kidney Foundation), as well as the Strategic Research Programme in Diabetes at Karolinska Institutet (Swedish Research Council grant no. 2009-1068) and other grants from the Swedish Research Council (no. 2018–00932).
Keywords:Ageing, chronic kidney disease, end-stage kidney disease, inflammation, premature ageing, senescence, uremic toxins.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Shiels, Professor Paul
Creator Roles:
Shiels, P.Writing – review and editing
Authors: Ebert, T., Pawelzik, S.-C., Witasp, A., Arefin, S., Hobson, S., Kublickiene, K., Shiels, P. G., Bäck, M., and Stenvinkel, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Toxins
Publisher:MDPI
ISSN:2072-6651
ISSN (Online):2072-6651
Published Online:04 April 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Toxins 12(4): 227
Publisher Policy:Reproduced under a Creative Commons Licence

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