Moving beyond standard procedures to assess spontaneous recognition memory

Ameen-Ali, K.E. , Easton, A. and Eacott, M.J. (2015) Moving beyond standard procedures to assess spontaneous recognition memory. Neuroscience and Biobehavioral Reviews, 53, pp. 37-51. (doi: 10.1016/j.neubiorev.2015.03.013) (PMID:25842032)

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Abstract

This review will consider how spontaneous tasks have been applied alongside neuroscientific techniques to test complex forms of recognition memory for objects and their environmental features, e.g. the spatial location of an object or the context in which it is presented. We discuss studies that investigate the roles of the perirhinal cortex and the hippocampus in recognition memory using standard testing paradigms, and consider how these findings contribute to the ongoing debate about whether recognition memory is a single unitary process or multiple processes that can be dissociated anatomically and functionally. Due to the wide use of spontaneous tasks, the need for improved procedures that reduce animal use is acknowledged, with multiple trial paradigms discussed as a novel way of reducing variability and animal numbers in these tasks. The importance of improving translation of animal models to humans is highlighted, with emphasis on a shift away from relying on the phenomenological experience of human subjects.

Item Type:Articles
Additional Information:This work was supported and funded by a National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) studentship to K. A-A (NC/K500252/1).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ameen-Ali, Dr Kamar
Authors: Ameen-Ali, K.E., Easton, A., and Eacott, M.J.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Neuroscience and Biobehavioral Reviews
Publisher:Elsevier
ISSN:0149-7634
ISSN (Online):1873-7528
Published Online:02 April 2015
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Neuroscience and Biobehavioral Reviews 53: 37-51
Publisher Policy:Reproduced under a Creative Commons License

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