Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease

Ameen-Ali, K.E. , Wharton, S.B., Simpson, J.E., Heath, P.R., Sharp, P. and Berwick, J. (2017) Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease. Neuropathology and Applied Neurobiology, 43(7), pp. 553-570. (doi: 10.1111/nan.12440) (PMID:28880417)

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Abstract

Our understanding of the underlying biology of Alzheimer's disease (AD) has been steadily progressing; however, this is yet to translate into a successful treatment in humans. The use of transgenic mouse models has helped to develop our understanding of AD, not only in terms of disease pathology, but also with the associated cognitive impairments typical of AD. Plaques and neurofibrillary tangles are often among the last pathological changes in AD mouse models, after neuronal loss and gliosis. There is a general consensus that successful treatments need to be applied before the onset of these pathologies and associated cognitive symptoms. This review discusses the different types of AD mouse models in terms of the temporal progression of the disease, how well they replicate the pathological changes seen in human AD and their cognitive defects. We provide a critical assessment of the behavioural tests used with AD mice to assess cognitive changes and decline, and discuss how successfully they correlate with cognitive impairments in humans with AD. This information is an important tool for AD researchers when deciding on appropriate mouse models, and when selecting measures to assess behavioural and cognitive change.

Item Type:Articles
Additional Information:This work was funded by an Alzheimer's Research UK Interdisciplinary Research Grant (ARUK‐IRG2014‐10).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ameen-Ali, Dr Kamar
Authors: Ameen-Ali, K.E., Wharton, S.B., Simpson, J.E., Heath, P.R., Sharp, P., and Berwick, J.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Neuropathology and Applied Neurobiology
Publisher:Wiley
ISSN:0305-1846
ISSN (Online):1365-2990
Published Online:07 September 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Neuropathology and Applied Neurobiology 43(7): 553-570
Publisher Policy:Reproduced under a Creative Commons License

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