Ameen-Ali, K.E. , Wharton, S.B., Simpson, J.E., Heath, P.R., Sharp, P. and Berwick, J. (2017) Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease. Neuropathology and Applied Neurobiology, 43(7), pp. 553-570. (doi: 10.1111/nan.12440) (PMID:28880417)
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Abstract
Our understanding of the underlying biology of Alzheimer's disease (AD) has been steadily progressing; however, this is yet to translate into a successful treatment in humans. The use of transgenic mouse models has helped to develop our understanding of AD, not only in terms of disease pathology, but also with the associated cognitive impairments typical of AD. Plaques and neurofibrillary tangles are often among the last pathological changes in AD mouse models, after neuronal loss and gliosis. There is a general consensus that successful treatments need to be applied before the onset of these pathologies and associated cognitive symptoms. This review discusses the different types of AD mouse models in terms of the temporal progression of the disease, how well they replicate the pathological changes seen in human AD and their cognitive defects. We provide a critical assessment of the behavioural tests used with AD mice to assess cognitive changes and decline, and discuss how successfully they correlate with cognitive impairments in humans with AD. This information is an important tool for AD researchers when deciding on appropriate mouse models, and when selecting measures to assess behavioural and cognitive change.
Item Type: | Articles |
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Additional Information: | This work was funded by an Alzheimer's Research UK Interdisciplinary Research Grant (ARUK‐IRG2014‐10). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Ameen-Ali, Dr Kamar |
Authors: | Ameen-Ali, K.E., Wharton, S.B., Simpson, J.E., Heath, P.R., Sharp, P., and Berwick, J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
Journal Name: | Neuropathology and Applied Neurobiology |
Publisher: | Wiley |
ISSN: | 0305-1846 |
ISSN (Online): | 1365-2990 |
Published Online: | 07 September 2017 |
Copyright Holders: | Copyright © 2017 The Authors |
First Published: | First published in Neuropathology and Applied Neurobiology 43(7): 553-570 |
Publisher Policy: | Reproduced under a Creative Commons License |
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