Malaria transmission through the mosquito requires the function of the OMD protein

Currà, C. et al. (2019) Malaria transmission through the mosquito requires the function of the OMD protein. PLoS ONE, 14(9), e0222226. (doi: 10.1371/journal.pone.0222226) (PMID:31553751) (PMCID:PMC6760768)

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Abstract

Ookinetes, one of the motile and invasive forms of the malaria parasite, rely on gliding motility in order to establish an infection in the mosquito host. Here we characterize the protein PBANKA_0407300 which is conserved in the Plasmodium genus but lacks significant similarity to proteins of other eukaryotes. It is expressed in gametocytes and throughout the invasive mosquito stages of P. berghei, but is absent from asexual blood stages. Mutants lacking the protein developed morphologically normal ookinetes that were devoid of productive motility although some stretching movement could be detected. We therefore named the protein Ookinete Motility Deficient (OMD). Several key factors known to be involved in motility however were normally expressed and localized in the mutant. Importantly, the mutant failed to establish an infection in the mosquito which resulted in a total malaria transmission blockade.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Lemgruber Soares, Dr Leandro
Creator Roles:
Lemgruber, L.Funding acquisition, Investigation, Methodology, Writing – review and editing
Authors: Currà, C., Kehrer, J., Lemgruber, L., Silva, P. A.G.C., Bertuccini, L., Superti, F., Pace, T., Ponzi, M., Frischknecht, F., Siden-Kiamos, I., and Mair, G. R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:PLoS ONE
Publisher:Public Library of Science
ISSN:1932-6203
ISSN (Online):1932-6203
Copyright Holders:Copyright © 2019 Currà et al.
First Published:First published in PLoS ONE 14(9): e0222226
Publisher Policy:Reproduced under a Creative Commons License

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