Centeno, A. , Xie, F. and Alford, N. (2013) Predicting the fluorescent enhancement rate by gold and silver nanospheres using finite-difference time-domain analysis. IET Nanobiotechnology, 7(2), pp. 50-58. (doi: 10.1049/iet-nbt.2012.0016) (PMID:24046905)
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Abstract
Metal-induced fluorescence enhancement (MIFE) is a promising strategy for increasing the sensitivity of fluorophores used in biological sensors. This study uses the finite-difference time-domain technique to predict the fluorescent enhancement rate of a fluorophore molecule in close proximity to a gold or silver spherical nanoparticle. By considering commercially available fluorescent dyes the computed results are compared with the published experimental data. The results show that MIFE is a complex coupling process between the fluorophore molecule and the metal nanoparticle. Nevertheless using computational electromagnetic techniques to perform calculations it is possible to calculate, with reasonable accuracy, the fluorescent enhancement. Using this methodology it will be possible to consider different shaped metal nanoparticles and any supporting substrate material in the future, an important step in building reliable biosensors capable of detecting low levels of proteins tagged with fluorescence molecules.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Centeno, Dr Anthony |
| Authors: | Centeno, A., Xie, F., and Alford, N. |
| College/School: | College of Science and Engineering > School of Engineering > Systems Power and Energy |
| Journal Name: | IET Nanobiotechnology |
| Publisher: | Institution of Engineering and Technology (IET) |
| ISSN: | 1751-8741 |
| ISSN (Online): | 1751-875X |
| Published Online: | 20 June 2013 |
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