Novel pathways that regulate tumor necrosis factor-alpha production in rheumatoid arthritis

Gracie, J., Leung, B. and McInnes, I. (2002) Novel pathways that regulate tumor necrosis factor-alpha production in rheumatoid arthritis. Current Opinion in Rheumatology, 14, pp. 270-275. (doi:10.1097/00002281-200205000-00013) (PMID:11981325)

Full text not currently available from Enlighten.

Abstract

Clinical intervention studies have clearly shown the benefit in suppressing tumor necrosis factor-alpha (TNF-alpha) rheumatoid arthritis (RA). In consequence, considerable interest has arisen in those pathways that in turn regulate TNF-alpha production, because they may offer further possible therapeutic targets. Several candidate pathways are currently being investigated. They include T cell/macrophage interactions mediated primarily through cell-cell membrane contact; novel cytokine activities; microbial-derived products, in particular bacterial deoxyribonucleic acid sequences; autoreactive T cells, and immunoglobulins. At the subcellular level, there is further interest in targeting signaling and mRNA processing and cytokine cleavage pathways required for optimal TNF-alpha production. The key recent observations in these areas, particularly in the extracellular compartment, are reviewed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain and Leung, Dr Bernard
Authors: Gracie, J., Leung, B., and McInnes, I.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Current Opinion in Rheumatology
ISSN:1040-8711

University Staff: Request a correction | Enlighten Editors: Update this record