Highly efficient spatially offset Raman spectroscopy to profile molecular composition in bone

Cui, H. , Glidle, A. and Cooper, J. M. (2020) Highly efficient spatially offset Raman spectroscopy to profile molecular composition in bone. IEEE Access, 8, pp. 62905-62911. (doi: 10.1109/ACCESS.2020.2984170)

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Abstract

Spatially offset Raman spectroscopy (SORS) offers the prospect of collecting spectral information detailing the molecular composition of biomaterials at greater depths below the surface layers than are normally probed by conventional Raman spectroscopy. By collecting off-axial scattered light, the technique overcomes the large background from in-line light within scattering media. In this paper we present a configuration which enables the highly efficient collection of spectral markers, indicative of bone health, including Raman signatures to assess phosphate, collagen and carbonate content, at millimeter depths. We demonstrate the effectiveness of the technique by performing spectral decompositions to analyze the molecular distribution of these markers non-invasively, using in vitro model systems, comprising bone and tissue, in situ.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cui, Dr Han and Cooper, Professor Jonathan and Glidle, Dr Andrew
Authors: Cui, H., Glidle, A., and Cooper, J. M.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:IEEE Access
Publisher:IEEE
ISSN:2169-3536
ISSN (Online):2169-3536
Published Online:30 March 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in IEEE Access 8: 62905-62911
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
173192Engineering growth factor microenvironments- a new therapeutic paradigm for regenerative medicineManuel Salmeron-SanchezEngineering and Physical Sciences Research Council (EPSRC)EP/P001114/1ENG - Biomedical Engineering