Association of the functional ovarian reserve with serum metabolomic profiling by nuclear magnetic resonance spectroscopy: a cross-sectional study of ~ 400 women

Al Rashid, K., Taylor, A., Lumsden, M. A. , Goulding, N., Lawlor, D. A. and Nelson, S. M. (2020) Association of the functional ovarian reserve with serum metabolomic profiling by nuclear magnetic resonance spectroscopy: a cross-sectional study of ~ 400 women. BMC Medicine, 18, 247. (doi: 10.1186/s12916-020-01700-z) (PMID:32862829) (PMCID:PMC7457540)

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Background: Women with diminished ovarian reserve are known to have increased cardiovascular risk, whether there is a continuous association between the ovarian reserve biomarkers; anti-Müllerian hormone (AMH), antral follicle count (AFC) and cardio-metabolic risk factors are unknown. Methods: A cross-sectional study of 398 women intending to undergo IVF with pre-treatment early follicular AMH and AFC measurements. Serum lipids, lipoprotein subclasses and low-molecular-weight metabolites were quantified by NMR spectroscopy (155 metabolic measures). Associations were analysed using multivariable regression. Results: Participants were mean 35.5 (SD 4.43) years old and had a median AMH of 16 pmol/l (IQR 8.8, 28.0 pmol/l) and a median AFC of 12 (IQR 7.16). AMH showed positive associations with HDL, omega-6 and polyunsaturated fatty acids and the amino acids isoleucine, leucine and tyrosine, with effects ranging from 0.11 (95%CI 0.004 to 0.21) for total lipids in small HDL to 0.16 (0.06 to 0.26) for isoleucine, for a mean difference of one SD of metabolite per one SD increment in AMH, and negatively with acetate: − 0.31(− 0.22, − 0.004) SD per 1 SD AMH. AFC was positively associated with alanine, glutamine and glycine. Results were consistent, though less precisely estimated, when restricted to those women who were preparing for treatment because of their partner’s infertility. Conclusions: In women intending to have IVF, AMH and AFC were not associated with traditional lipid measured but were associated with a number of novel cardiovascular risk factors. Prospective studies will be required for replication, determination of causality and confirmation that ovarian reserve is impacting on metabolism rather than variation in metabolism is influencing ovarian reserve.

Item Type:Articles
Additional Information:This work was supported by a Kuwait Government Fellowship to KA, the National Institute for Health Research Biomedical Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol (AT, DAL, and SMN), a European Research Council grant (DevelopObese; 669545 to DAL), European Union’s Horizon 2020 research and innovation programme (LifeCycle; 733206 to DA), a British Heart Foundation Grant (AA/18/7/34219 to DAL) and a National Institute for Health Research Senior Investigator award (NF-0616-10102 to DAL). AT, NG and DAL work in a Unit that receives support from the University of Bristol and the MRC (MC_UU_00011/6).
Glasgow Author(s) Enlighten ID:Nelson, Professor Scott and Lumsden, Professor Mary
Authors: Al Rashid, K., Taylor, A., Lumsden, M. A., Goulding, N., Lawlor, D. A., and Nelson, S. M.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:BMC Medicine
Publisher:BioMed Central
ISSN (Online):1741-7015
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in BMC Medicine 18: 247
Publisher Policy:Reproduced under a Creative Commons License

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