Ageing dangerously; homing of senescent CD8 T cells in cutaneous Leishmaniasis

Milling, S. (2020) Ageing dangerously; homing of senescent CD8 T cells in cutaneous Leishmaniasis. Immunology, 159(4), pp. 355-356. (doi: 10.1111/imm.13188) (PMID:32182636)

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Abstract

Both CD8+ T cells and NK cells contribute to the immune response against the protozoan Leishmania parasite. Both are able to generate IFN‐γ and both display cytotoxic features. These features may enable them to not only contribute to parasite clearance but also to cause immune‐mediated pathology. This pathology is evident, for example, in the Leismania‐induced skin lesions found in patients with cutaneous leismaniasis (CL). Here we highlight new data demonstrating that CD8+ T cells and NK cells in CL display a highly cytotoxic senescent phenotype, and that the senescent T cells play a major role in mediating skin pathology. This is the first demonstration that senescent CD8 T cells contribute to immunopathology in vivo.

Item Type:Articles (Editorial)
Keywords:Immunology, immunology and allergy.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Milling, Professor Simon
Authors: Milling, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Immunology
Publisher:Wiley
ISSN:0019-2805
ISSN (Online):1365-2567
Published Online:17 March 2020
Copyright Holders:Copyright © 2020 John Wiley and Sons Ltd
First Published:First published in Immunology 159(4): 355-356
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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