Milling, S. (2020) Ageing dangerously; homing of senescent CD8 T cells in cutaneous Leishmaniasis. Immunology, 159(4), pp. 355-356. (doi: 10.1111/imm.13188) (PMID:32182636)
|
Text
212788.pdf - Accepted Version 189kB |
Abstract
Both CD8+ T cells and NK cells contribute to the immune response against the protozoan Leishmania parasite. Both are able to generate IFN‐γ and both display cytotoxic features. These features may enable them to not only contribute to parasite clearance but also to cause immune‐mediated pathology. This pathology is evident, for example, in the Leismania‐induced skin lesions found in patients with cutaneous leismaniasis (CL). Here we highlight new data demonstrating that CD8+ T cells and NK cells in CL display a highly cytotoxic senescent phenotype, and that the senescent T cells play a major role in mediating skin pathology. This is the first demonstration that senescent CD8 T cells contribute to immunopathology in vivo.
| Item Type: | Articles (Editorial) |
|---|---|
| Keywords: | Immunology, immunology and allergy. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Milling, Professor Simon |
| Authors: | Milling, S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
| Journal Name: | Immunology |
| Publisher: | Wiley |
| ISSN: | 0019-2805 |
| ISSN (Online): | 1365-2567 |
| Published Online: | 17 March 2020 |
| Copyright Holders: | Copyright © 2020 John Wiley and Sons Ltd |
| First Published: | First published in Immunology 159(4): 355-356 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric