Riley, J. S. and Tait, S. W.G. (2020) Mitochondrial DNA in inflammation and immunity. EMBO Reports, 21(4), e49799. (doi: 10.15252/embr.201949799) (PMID:32202065) (PMCID:PMC7132203)
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Abstract
Mitochondria are cellular organelles that orchestrate a vast range of biological processes, from energy production and metabolism to cell death and inflammation. Despite this seemingly symbiotic relationship, mitochondria harbour within them a potent agonist of innate immunity: their own genome. Release of mitochondrial DNA into the cytoplasm and out into the extracellular milieu activates a plethora of different pattern recognition receptors and innate immune responses, including cGAS‐STING, TLR9 and inflammasome formation leading to, among others, robust type I interferon responses. In this Review, we discuss how mtDNA can be released from the mitochondria, the various inflammatory pathways triggered by mtDNA release and its myriad biological consequences for health and disease.
Item Type: | Articles |
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Additional Information: | Research in our laboratory is supported by funding from Cancer Research UK and Prostate Cancer UK. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Riley, Dr Joel and Tait, Professor Stephen |
Authors: | Riley, J. S., and Tait, S. W.G. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | EMBO Reports |
Publisher: | EMBO Press |
ISSN: | 1469-221X |
ISSN (Online): | 1469-3178 |
Published Online: | 23 March 2020 |
Copyright Holders: | Copyright © 2020 The Authors |
First Published: | First published in EMBO Reports 21(4): e39799 |
Publisher Policy: | Reproduced under a Creative Commons License |
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