Garzón-Posse, F., Prunet, J. and Gamba-Sánchez, D. (2020) An alternative approach to the synthesis of the three fragments of Anachelin H. Organic and Biomolecular Chemistry, 18(14), pp. 2702-2715. (doi: 10.1039/D0OB00315H)
Text
212422.pdf - Accepted Version 723kB |
Abstract
The synthesis of the fully protected peptide, polyketide and alkaloid fragments of Anachelin H are presented. The peptide fragment was prepared using a liquid phase peptide synthesis; the polyketide fragment was synthetized using a cross metathesis and an intramolecular oxa-Michael reaction as the key steps to introduce the desired stereochemistry; finally, the alkaloid fragment was obtained by an oxidative cyclization of a catechol derivative using potassium ferricyanide. Experiments to illustrate the coupling of fragments and the effectiveness of the convergent strategy are also described.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Prunet, Dr Joelle |
Authors: | Garzón-Posse, F., Prunet, J., and Gamba-Sánchez, D. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Organic and Biomolecular Chemistry |
Publisher: | Royal Society of Chemistry |
ISSN: | 1477-0520 |
ISSN (Online): | 1477-0539 |
Published Online: | 18 March 2020 |
Copyright Holders: | Copyright © 2020 The Royal Society of Chemistry |
First Published: | First published in Organic and Biomolecular Chemistry 18(14): 2702-2715 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
University Staff: Request a correction | Enlighten Editors: Update this record