Prevalence and speciation of brucellosis in febrile patients from a pastoralist community of Tanzania

Bodenham, R. F. et al. (2020) Prevalence and speciation of brucellosis in febrile patients from a pastoralist community of Tanzania. Scientific Reports, 10, 7081. (doi: 10.1038/s41598-020-62849-4) (PMID:32341414) (PMCID:PMC7184621)

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Abstract

Brucellosis is an endemic zoonosis in sub-Saharan Africa. Pastoralists are at high risk of infection but data on brucellosis from these communities are scarce. The study objectives were to: estimate the prevalence of human brucellosis, identify the Brucella spp. causing illness, describe non-Brucella bloodstream infections, and identify risk factors for brucellosis in febrile patients from a pastoralist community of Tanzania. Fourteen (6.1%) of 230 participants enrolled between August 2016 and October 2017 met study criteria for confirmed (febrile illness and culture positivity or ≥four-fold rise in SAT titre) or probable (febrile illness and single SAT titre ≥160) brucellosis. Brucella spp. was the most common bloodstream infection, with B. melitensis isolated from seven participants and B. abortus from one. Enterococcus spp., Escherichia coli, Salmonella enterica, Staphylococcus aureus and Streptococcus pneumoniae were also isolated. Risk factors identified for brucellosis included age and herding, with a greater probability of brucellosis in individuals with lower age and who herded cattle, sheep or goats in the previous 12 months. Disease prevention activities targeting young herders have potential to reduce the impacts of human brucellosis in Tanzania. Livestock vaccination strategies for the region should include both B. melitensis and B. abortus.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Haydon, Professor Daniel and Lukambagire, Mr Abdulhamid and Halliday, Dr Jo and Bodenham, Dr Rebecca and Thomas, Dr Kate
Authors: Bodenham, R. F., Lukambagire, A., Ashford, R. T., Buza, J. J., Cash-Goldwasser, S., Crump, J. A., Kazwala, R. R., Maro, V. P., McGiven, J., Mkenda, N., Mmbaga, B. T., Rubach, M. P., Sakasaka, P., Shirima, G. M., Swai, E. S., Thomas, K. M., Whatmore, A. M., Haydon, D. T., and Halliday, J. E.B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Scientific Reports
Publisher:Nature Research
ISSN:2045-2322
ISSN (Online):2045-2322
Published Online:27 April 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Scientific Reports 10:7081
Publisher Policy:Reproduced under a Creative Commons licence
Data DOI:10.5525/gla.researchdata.978

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190785Molecular epidemology of brucellosis in northern TanzaniaDaniel HaydonBiotechnology and Biological Sciences Research Council (BBSRC)BB/L018845/1Institute of Biodiversity, Animal Health and Comparative Medicine
170521A One-Health approach to dissecting the diverse zoonotic causes of non-malaria febrile illnessDaniel HaydonThe Royal Society (ROYSOC)AA130131Institute of Biodiversity, Animal Health and Comparative Medicine
171979Zoonoses and Emerging Livestock Systems ZELS Reducing the risk to livestock and people programme associated studentships - ZELS-ASSarah CleavelandBiotechnology and Biological Sciences Research Council (BBSRC)BB/N503563/1Institute of Biodiversity, Animal Health and Comparative Medicine
190825Social, economic and environmental drivers of zoonoses in Tanzania (SEEDZ)Sarah CleavelandBiotechnology and Biological Sciences Research Council (BBSRC)BB/L018926/1Institute of Biodiversity, Animal Health and Comparative Medicine
190821Hazards associated with zoonotic enteric pathogens in emerging livestock meat pathways (HAZEL)Ruth ZadoksBiotechnology and Biological Sciences Research Council (BBSRC)BB/L017679/1Institute of Biodiversity, Animal Health and Comparative Medicine