Benavides, J. A., Velasco-Villa, A., Godino, L. C., Satheshkumar, P. S., Ruby, N., Rojas-Paniagua, E., Shiva, C., Falcon, N. and Streicker, D. G. (2020) Abortive vampire bat rabies infections in Peruvian peridomestic livestock. PLoS Neglected Tropical Diseases, 14(6), e0008194. (doi: 10.1371/journal.pntd.0008194) (PMID:32598388) (PMCID:PMC7351222)
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Abstract
Rabies virus infections normally cause universally lethal encephalitis across mammals. However, ‘abortive infections’ which are resolved prior to the onset of lethal disease have been described in bats and a variety of non-reservoir species. Here, we surveyed rabies virus neutralizing antibody titers in 332 unvaccinated livestock of 5 species from a vampire bat rabies endemic region of southern Peru where livestock are the main food source for bats. We detected rabies virus neutralizing antibody titers in 11, 5 and 3.6% of cows, goats and sheep respectively and seropositive animals did not die from rabies within two years after sampling. Seroprevalence was correlated with the number of local livestock rabies mortalities reported one year prior but also one year after sample collection. This suggests that serological status of livestock can indicate the past and future levels of rabies risk to non-reservoir hosts. To our knowledge, this is the first report of anti-rabies antibodies among goats and sheep, suggesting widespread abortive infections among livestock in vampire bat rabies endemic areas. Future research should resolve the within-host biology underlying clearance of rabies infections. Cost-effectiveness analyses are also needed to evaluate whether serological monitoring of livestock can be a viable complement to current monitoring of vampire bat rabies risk based on animal mortalities alone.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Benavides, Dr Julio and Streicker, Professor Daniel |
| Creator Roles: | Benavides, J. A.Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review and editing Streicker, D. G.Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review and editing |
| Authors: | Benavides, J. A., Velasco-Villa, A., Godino, L. C., Satheshkumar, P. S., Ruby, N., Rojas-Paniagua, E., Shiva, C., Falcon, N., and Streicker, D. G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | PLoS Neglected Tropical Diseases |
| Publisher: | Public Library of Science |
| ISSN: | 1935-2727 |
| ISSN (Online): | 1935-2735 |
| Copyright Holders: | This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose |
| First Published: | First published in PLoS Neglected Tropical Diseases 14(6): e0008194 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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