Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases

Kanaji, S. et al. (2007) Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases. FEBS Letters, 581, pp. 4260-4264. (doi:10.1016/j.febslet.2007.07.072)

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Publisher's URL: http://dx.doi.org/10.1016/j.febslet.2007.07.072


The physiological significance of the squamous cell carcinoma antigens 1 (SCCA1) and SCCA2, members of the ovalbumin serpin family, remains unresolved. In this study, we examined whether SCCA1 or SCCA2 inhibits protozoa- or helminth-derived cysteine proteases. SCCA1, but not SCCA2, potently inhibited the cysteine protease activities of CPB2.8 from Leishmania mexicana, cruzain from Trypanosoma cruzi, rhodesain from Trypanosoma brucei rhodesience, and cathepsin L2 from Fasciola hepatica. The inhibitory activities of SCCA1 were due to its resistance to cleavage by the cysteine proteases. The findings indicate that induction of cysteine protease inhibitors might be a novel defense mechanism against parasite development.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Coombs, Professor Graham and Mottram, Professor Jeremy
Authors: Kanaji, S., Tanaka, Y., Sakata, Y., Takeshita, K., Arima, K., Ohta, S., Hansell, E. J., Caffrey, C., Mottram, J. C., Lowther, J., Donnelly, S., Stack, C., Kadowaki, T., Yamamoto, K., McKerrow, J. H., Dalton, J. P., Coombs, G. H., and Izuhara, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:FEBS Letters
ISSN (Online):1873-3468
Published Online:09 August 2007
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
297261Post-genomic analysis of cysteine protease function in Leishmania parasitesJeremy MottramMedical Research Council (MRC)G0000508Infection Immunity and Inflammation Life Sciences