Kanaji, S. et al. (2007) Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases. FEBS Letters, 581, pp. 4260-4264. (doi: 10.1016/j.febslet.2007.07.072)
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Publisher's URL: http://dx.doi.org/10.1016/j.febslet.2007.07.072
Abstract
The physiological significance of the squamous cell carcinoma antigens 1 (SCCA1) and SCCA2, members of the ovalbumin serpin family, remains unresolved. In this study, we examined whether SCCA1 or SCCA2 inhibits protozoa- or helminth-derived cysteine proteases. SCCA1, but not SCCA2, potently inhibited the cysteine protease activities of CPB2.8 from Leishmania mexicana, cruzain from Trypanosoma cruzi, rhodesain from Trypanosoma brucei rhodesience, and cathepsin L2 from Fasciola hepatica. The inhibitory activities of SCCA1 were due to its resistance to cleavage by the cysteine proteases. The findings indicate that induction of cysteine protease inhibitors might be a novel defense mechanism against parasite development.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Coombs, Professor Graham and Mottram, Professor Jeremy |
Authors: | Kanaji, S., Tanaka, Y., Sakata, Y., Takeshita, K., Arima, K., Ohta, S., Hansell, E. J., Caffrey, C., Mottram, J. C., Lowther, J., Donnelly, S., Stack, C., Kadowaki, T., Yamamoto, K., McKerrow, J. H., Dalton, J. P., Coombs, G. H., and Izuhara, K. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | FEBS Letters |
Publisher: | Elsevier |
ISSN: | 0014-5793 |
ISSN (Online): | 1873-3468 |
Published Online: | 09 August 2007 |
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