UK stillbirth trends in over 11 million births provide no evidence to support effectiveness of Growth Assessment Protocol program

Iliodromiti, S., Smith, G.C.S., Lawlor, D.A., Pell, J.P. and Nelson, S.M. (2020) UK stillbirth trends in over 11 million births provide no evidence to support effectiveness of Growth Assessment Protocol program. Ultrasound in Obstetrics and Gynecology, 55(5), pp. 599-604. (doi: 10.1002/uog.21999) (PMID:32266750)

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OBJECTIVE:Use of the Growth Assessment Protocol (GAP) has increased internationally under the assumption that it reduces the stillbirth rate. The evidence for this is limited and based largely on an ecological time-trend study. Discordance in the uptake of the GAP program between Scotland and England/Wales enabled us to assess the assertion that implementation of GAP leads to a reduced stillbirth rate. METHODS:We analyzed data from the National Records for Scotland and the Office for National Statistics on the number of singleton maternities and stillbirths in Scotland and in England and Wales, respectively, from 1 January 2000 to 31 December 2015. National uptake of the GAP program over time in each of the regions was recorded. Stillbirth rate per 1000 maternities was calculated, according to year of delivery, and compared between Scotland and England/Wales. RESULTS:During the study period, there were 870 632 singleton maternities in Scotland, of which 4243 were stillbirths, and there were 10 469 120 singleton maternities in England and Wales, of which 51 562 were stillbirths. There was a marked difference in uptake of the GAP program between the two regions, with substantially fewer maternity units in Scotland implementing the program. Stillbirth rates were static up to 2010, with a decline thereafter in both regions, to 3.75 (95% CI, 3.25-4.30) per 1000 maternities in Scotland and 4.30 (95% CI, 4.15-4.46) per 1000 maternities in England and Wales in 2015. From 2010 onwards, the decline in Scotland was faster, equating to 48 (95% CI, 47.9-48.1) fewer stillbirths per 100 000 maternities in Scotland than in England and Wales from 2010 to 2015 compared with 2000 to 2009. CONCLUSIONS:We observed a decline in stillbirth rate in England and Wales, which coincided with implementation of the GAP program. However, a concurrent decline in stillbirth rate was observed in Scotland in the absence of increased implementation of GAP. The secular rates of change in stillbirth rate in England and Wales cannot be used to infer efficacy of the GAP program.

Item Type:Articles
Additional Information:Funding: Medical Research Council. Grant Numbers: MC_UU_12013/5, MR/N015177/1 National Institute for Health Research. Grant Number: NF‐SI‐0611‐10196 NIHR Biomedical Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol.
Glasgow Author(s) Enlighten ID:Nelson, Professor Scott and Pell, Professor Jill and Iliodromiti, Dr Stamatina
Authors: Iliodromiti, S., Smith, G.C.S., Lawlor, D.A., Pell, J.P., and Nelson, S.M.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
Journal Name:Ultrasound in Obstetrics and Gynecology
ISSN (Online):1469-0705
Published Online:07 April 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Ultrasound in Obstetrics and Gynecology 55(5):599-604
Publisher Policy:Reproduced under a Creative Commons licence

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