Serum anti-Müllerian hormone in the prediction of response to hCG stimulation in children with DSD

Lucas-Herald, A. K. , Kyriakou, A., Alimussina, M., Guaragna-Filho, G., Diver, L. A., McGowan, R., Smith, K., McNeilly, J. D. and Ahmed, S. F. (2020) Serum anti-Müllerian hormone in the prediction of response to hCG stimulation in children with DSD. Journal of Clinical Endocrinology and Metabolism, 105(5), pp. 1608-1616. (doi: 10.1210/clinem/dgaa052) (PMID:32016383) (PMCID:PMC7096311)

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Abstract

The relationship between serum anti-Müllerian hormone (AMH) and the testosterone response to hCG stimulation test is unclear. Children who had hCG stimulation tests in one tertiary centre between 2001-2018 were included (n,138). Serum testosterone (T) was measured before (D1) and after 3 days (D4) of hCG stimulation. Sixty-one of these children also had prolonged hCG stimulation for 2 more weeks and serum T measured after 21 days (D22). All children had a serum AMH measured on D1. Of the 138 children, D4 T was normal in 104 (75%). AMH was low in 24/138 (17%) children and 16 (67%) of these had a low D4 testosterone. Median AMH in those who had a normal vs low D4 T was 850 pmol/l (24, 2280) and 54 pmol/l (0.4, 1664), respectively (p<0.0001). An AMH >5th centile was associated with a low D4 testosterone in 18/118 (13%, p<0.0001). Of the 61 children who had prolonged hCG stimulation, D22 T was normal in 39 (64%). AMH was low in 10/61(16%) children and 9 (90%) of these had a low D22 testosterone. Median AMH in children who responded and did not respond by D22 was 639 pmol/l (107, 2280) and 261 pmol/l (15, 1034) (p<0.0001). A normal AMH may provide valuable information on overall testicular function. However, a low AMH does not necessarily predict a sub-optimal testosterone response to hCG stimulation. [Abstract copyright: © Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.]

Item Type:Articles
Keywords:AMH, androgen, DSD, testes.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Diver, Miss Louise and Ahmed, Professor Syed Faisal and Smith, Ms Karen and Mcneilly, Dr Jane and Alimussina, Dr Malika and Kyriakou, Dr Andreas and Lucas-Herald, Dr Angela
Authors: Lucas-Herald, A. K., Kyriakou, A., Alimussina, M., Guaragna-Filho, G., Diver, L. A., McGowan, R., Smith, K., McNeilly, J. D., and Ahmed, S. F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Journal of Clinical Endocrinology and Metabolism
Publisher:Oxford University Press
ISSN:0021-972X
ISSN (Online):1945-7197
Published Online:04 February 2020

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