The role of WNT signalling in urothelial cell carcinoma

Ahmad, I. (2015) The role of WNT signalling in urothelial cell carcinoma. Annals of the Royal College of Surgeons of England, 97(7), pp. 481-486. (doi: 10.1308/rcsann.2015.0008) (PMID:26274747) (PMCID:PMC5210134)

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Abstract

Urothelial cell carcinoma (UCC) of the bladder is one of the most common malignancies, causing considerable morbidity and mortality worldwide. It is unique among the epithelial carcinomas as two distinct pathways to tumourigenesis appear to exist: low grade, recurring papillary tumours usually contain oncogenic mutations in FGFR3 or HRAS whereas high grade, muscle invasive tumours with metastatic potential generally have defects in the pathways controlled by the tumour suppressors p53 and retinoblastoma. Over the last two decades, a number of transgenic mouse models of UCC, containing deletions or mutations of key tumour suppressor genes or oncogenes, have helped us understand the mechanisms behind tumour development. In this summary, I present my work investigating the role of the WNT signalling cascade in UCC.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ahmad, Dr Imran
Authors: Ahmad, I.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Annals of the Royal College of Surgeons of England
Publisher:Royal College of Surgeons of England
ISSN:0035-8843
Copyright Holders:Copyright © 2014 The Royal College of Surgeons of England
First Published:First published in Annals of the Royal College of Surgeons of England 97(7):481-486
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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