Jamieson, N.B., Brown, D.J.F., Wallace, A.M. and McMillan, D.C. (2004) Adiponectin and the systemic inflammatory response in weight-losing patients with non-small cell lung cancer. Cytokine, 27(2-3), pp. 90-92. (doi: 10.1016/j.cyto.2004.03.017)
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Publisher's URL: http://dx.doi.org/10.1016/j.cyto.2004.03.017
Abstract
The aim of the present study was to examine the relationship between adiponectin and the systemic inflammatory response in weight-losing patients with non-small cell lung cancer (NSCLC). Measurement of anthropometry, acute phase proteins, interleukin-6, leptin (total and free) and adiponectin were carried out on healthy subjects (n=13) and non-small cell lung cancer patients with weight loss (n=20). The groups were age and sex matched. Compared with the controls the cancer group had a lower BMI (p<0.01), mid-upper arm circumference (p<0.001), triceps skinfold thickness (p<0.05) and circulating concentrations of albumin (p<0.001), haemoglobin (p<0.05), free and total leptin (p<0.05) and adiponectin (p<0.01). In contrast, the cancer group had elevated circulating concentrations of interleukin-6 and C-reactive protein concentrations (p<0.001). In the cancer group circulating adiponectin concentrations were significantly inversely correlated with both free (rs=−0.675, p=0.001) and total leptin concentrations (rs=−0.690, p=0.001). However, neither weight loss, interleukin-6 or C-reactive protein concentrations were correlated with either adiponectin, free or total leptin concentrations in the cancer group. These results suggest that adipokine production is normal and is unlikely to play a major role in the abnormal fat metabolism in weight-losing cancer patients.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Jamieson, Professor Nigel and McMillan, Professor Donald |
Authors: | Jamieson, N.B., Brown, D.J.F., Wallace, A.M., and McMillan, D.C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Cytokine |
ISSN: | 1043-4666 |
ISSN (Online): | 1096-0023 |
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