The stressful tumour environment drives plasticity of cell migration programmes, contributing to metastasis

Nikolaou, S. and Machesky, L. (2020) The stressful tumour environment drives plasticity of cell migration programmes, contributing to metastasis. Journal of Pathology, 250(5), pp. 612-623. (doi: 10.1002/path.5395) (PMID:32057095) (PMCID:PMC7216910)

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Tumours evolve to cope with environmental stresses or challenges such as nutrient starvation, depletion of survival factors and unbalanced mechanical forces. The uncontrolled growth and aberrant deregulation of core cell homeostatic pathways induced by genetic mutations creates an environment of stress. Here, we explore how the adaptations of tumours to the changing environment can drive changes in the motility machinery of cells, affecting migration, invasion and metastasis. Tumour cells can invade individually or collectively, or they can be extruded out of the surrounding epithelium. These mechanisms are thought to be modifications of normal processes occurring during development or tissue repair. Therefore, tumours may activate these pathways in response to environmental stresses, enabling them to survive in hostile environments and spread to distant sites.

Item Type:Articles
Additional Information:We thank Cancer research UK for core funding to LMM on grant A15673.
Glasgow Author(s) Enlighten ID:Machesky, Professor Laura and Nikolaou, Savvas
Authors: Nikolaou, S., and Machesky, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Journal of Pathology
ISSN (Online):1096-9896
Published Online:14 February 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Journal of Pathology 25(5):612-623
Publisher Policy:Reproduced under a Creative Commons license

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