Nikolaou, S. and Machesky, L. (2020) The stressful tumour environment drives plasticity of cell migration programmes, contributing to metastasis. Journal of Pathology, 250(5), pp. 612-623. (doi: 10.1002/path.5395) (PMID:32057095) (PMCID:PMC7216910)
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Abstract
Tumours evolve to cope with environmental stresses or challenges such as nutrient starvation, depletion of survival factors and unbalanced mechanical forces. The uncontrolled growth and aberrant deregulation of core cell homeostatic pathways induced by genetic mutations creates an environment of stress. Here, we explore how the adaptations of tumours to the changing environment can drive changes in the motility machinery of cells, affecting migration, invasion and metastasis. Tumour cells can invade individually or collectively, or they can be extruded out of the surrounding epithelium. These mechanisms are thought to be modifications of normal processes occurring during development or tissue repair. Therefore, tumours may activate these pathways in response to environmental stresses, enabling them to survive in hostile environments and spread to distant sites.
Item Type: | Articles |
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Additional Information: | We thank Cancer research UK for core funding to LMM on grant A15673. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Machesky, Professor Laura and Nikolaou, Savvas |
Authors: | Nikolaou, S., and Machesky, L. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Life Sciences |
Journal Name: | Journal of Pathology |
Publisher: | Wiley |
ISSN: | 0022-3417 |
ISSN (Online): | 1096-9896 |
Published Online: | 14 February 2020 |
Copyright Holders: | Copyright © 2020 The Authors |
First Published: | First published in Journal of Pathology 25(5):612-623 |
Publisher Policy: | Reproduced under a Creative Commons license |
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