Lymph node ratio may predict relapse free survival and overall survival in patients with stage II & III colorectal carcinoma

Zekri, J., Ahmad, I. , Elkhodary, T.R., Al-Gahmi, A., Hassouna, A., El Sayed, M.E., Ur Rehman, J., Karim, S.M. and Bin Sadiq, B. (2015) Lymph node ratio may predict relapse free survival and overall survival in patients with stage II & III colorectal carcinoma. Hepato-Gastroenterology, 62(138), pp. 291-294. (PMID:25916051)

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Abstract

Background/Aims: Lymph node ratio (LNR) defined as the number of lymph nodes (LNs) involved with metastases divided by number of LNs examined, has been shown to be an independent prognostic factor in breast, stomach and various other solid tumors. Its significance as a prognostic determinant in colorectal cancer (CRC) is still under investigation. This study investigated the prognostic value of LNR in patients with resected CRC. Methodology: We retrospectively examined 145 patients with stage II & III CRC diagnosed and treated at a single institution during 9 years pe- riod. Patients were grouped according to LNR in three groups. Group 1; LNR < 0.05, Group 2; LNR = 0.05-0.19 & Group 3 > 0.19. Chi square, life table analysis and multivariate Cox regression were used for statistical analysis. Results: On multivariate analysis, number of involved LNs (NILN) (HR = 1.15, 95% CI 1.055-1.245; P = 0.001) and pathological T stage (P = 0.002) were statistically significant predictors of relapse free survival (RFS). LNR as a continuous variable (but not as a categorical variable) was statistically significant predictor of RFS (P = 0.02). LNR was also a statistically significant predictor of overall survival (OS) (P = 0.02). Conclusion: LNR may predict RFS and OS in patients with resected stage II & III CRC. Studies with larger cohorts and longer follow up are needed to further examine and validate theprognostic value of LNR.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ahmad, Dr Imran
Authors: Zekri, J., Ahmad, I., Elkhodary, T.R., Al-Gahmi, A., Hassouna, A., El Sayed, M.E., Ur Rehman, J., Karim, S.M., and Bin Sadiq, B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Hepato-Gastroenterology
Publisher:Thieme Publishing
ISSN:0172-6390

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