Berrones‐Reyes, J. C., Muñoz‐Flores, B. M., Uscanga‐Palomeque, A. C., Santillán, R., Del Angel‐Mosqueda, C., Nobis, D., Cochrane, M. A., Magennis, S. and Jiménez‐Pérez, V. M. (2020) Two‐photon detection of organotin Schiff base complexes in cancer cells. ChemistrySelect, 5(5), pp. 1623-1627. (doi: 10.1002/slct.201904816)
|
Text
210133.pdf - Accepted Version 2MB | |
|
Text
210133Suppl.pdf - Supplemental Material 4MB |
Abstract
The early detection of cancer cells and their visualization before and after surgery are essential for successful pre‐ and post‐operative disease management. Although fluorescence imaging is a sensitive and versatile tool that is finding increasing use in clinical applications, there is a lack of tumour‐targeting fluorophores. We report here a family of fluorescent Schiff base organotin dyes (1: Et2N−L‐SnPh2, 2: Et2N−L‐SnBu2, 3: MeO−L‐SnPh2, 4: MeO−L‐SnBu2, 5: HO−L‐SnPh2, and 6: HO−L‐SnBu2, where L=2‐hydroxybenzylidene‐4‐hydroxybenzhydrazine). In addition to one‐photon‐excited fluorescence, efficient two‐photon excitation was demonstrated in compounds 1–4. Two of the compounds (5 and 6), both with hydroxyl substituents, were capable of selective accumulation in HeLa cells, allowing differentiation from normal cells (periodontal ligament cells). Compounds 1 and 3 showed excellent cancer cell staining (HeLa) using two‐photon bioimaging, which is promising for biomedicine applications.
| Item Type: | Articles |
|---|---|
| Additional Information: | The authors thank CONACYT (grant: 240011). J. C. Berrones‐Reyes thanks CONACYT for a PhD scholarship and D. Nobis thanks EPSRC for a PhD studentship. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Magennis, Dr Steven and Nobis, Mr David |
| Authors: | Berrones‐Reyes, J. C., Muñoz‐Flores, B. M., Uscanga‐Palomeque, A. C., Santillán, R., Del Angel‐Mosqueda, C., Nobis, D., Cochrane, M. A., Magennis, S., and Jiménez‐Pérez, V. M. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | ChemistrySelect |
| Publisher: | Wiley |
| ISSN: | 2365-6549 |
| ISSN (Online): | 2365-6549 |
| Published Online: | 03 February 2020 |
| Copyright Holders: | Copyright © 2020 Wiley-VCH Verlag GmbH and Co. KGaA |
| First Published: | First published in ChemistrySelect 5(5): 1623-1627 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric