Sunzini, F., De Stefano, S., Chimenti, M. S. and Melino, S. (2020) Hydrogen sulfide as potential regulatory gasotransmitter in arthritic diseases. International Journal of Molecular Sciences, 21(4), 1180. (doi: 10.3390/ijms21041180) (PMID:32053981) (PMCID:PMC7072783)
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Abstract
The social and economic impact of chronic inflammatory diseases, such as arthritis, explains the growing interest of the research in this field. The antioxidant and anti-inflammatory properties of the endogenous gasotransmitter hydrogen sulfide (H2S) were recently demonstrated in the context of different inflammatory diseases. In particular, H2S is able to suppress the production of pro-inflammatory mediations by lymphocytes and innate immunity cells. Considering these biological effects of H2S, a potential role in the treatment of inflammatory arthritis, such as rheumatoid arthritis (RA), can be postulated. However, despite the growing interest in H2S, more evidence is needed to understand the pathophysiology and the potential of H2S as a therapeutic agent. Within this review, we provide an overview on H2S biological effects, on its role in immune-mediated inflammatory diseases, on H2S releasing drugs, and on systems of tissue repair and regeneration that are currently under investigation for potential therapeutic applications in arthritic diseases.
| Item Type: | Articles |
|---|---|
| Additional Information: | A correction to this article is available at https://doi.org/10.3390/ijms21176134. |
| Keywords: | Inflammation, arthritis, organosulfur compounds, oxidative stress, stem-cell therapy, H2S-releasing biomaterials, non-steroidal anti-inflammatory drugs (NSAIDs). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Sunzini, Miss Flavia |
| Creator Roles: | |
| Authors: | Sunzini, F., De Stefano, S., Chimenti, M. S., and Melino, S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | International Journal of Molecular Sciences |
| Publisher: | MDPI |
| ISSN: | 1661-6596 |
| ISSN (Online): | 1422-0067 |
| Published Online: | 11 February 2020 |
| Copyright Holders: | Copyright © 2020 The Authors |
| First Published: | First published in International Journal of Molecular Sciences 21(4): 1180 |
| Publisher Policy: | Reproduced under a Creative Commons License |
| Related URLs: |
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