UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings

McFall, A. et al. (2020) UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings. Journal of Cerebral Blood Flow and Metabolism, 40(7), pp. 1402-1414. (doi: 10.1177/0271678X20910552) (PMID:32151228) (PMCID:PMC7307003)

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Abstract

Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine underlying variability and what could be implemented to overcome identified challenges. Twelve UK VCI research centres were identified and invited to complete a questionnaire and attend a one-day workshop. Questionnaire responses demonstrated agreement that outcome assessments in VCI preclinical research vary by group and even those common across groups, may be performed differently. From the workshop, six themes were discussed: issues with preclinical models, reasons for choosing functional assessments, issues in interpretation of functional assessments, describing and reporting functional outcome assessments, sharing resources and expertise, and standardization of outcomes. Eight consensus points emerged demonstrating broadly that the chosen assessment should reflect the deficit being measured, and therefore that one assessment does not suit all models; guidance/standardisation on recording VCI outcome reporting is needed and that uniformity would be aided by a platform to share expertise, material, protocols and procedures thus reducing heterogeneity and so increasing potential for collaboration, comparison and replication. As a result of the workshop, UK wide consensus statements were agreed and future priorities for preclinical research identified.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hietamies, Miss Tuuli and Brezzo, Dr Gaia and McCabe, Dr Chris and McFall, Ms Aisling and Miller, Dr Alyson and Work, Dr Lorraine and Quinn, Dr Terry and Bernard, Mr Ashton and Touyz, Professor Rhian
Authors: McFall, A., Hietamies, T. M., Bernard, A., Aimable, M., Allan, S. M., Bath, P. M., Brezzo, G., Carrare, R. O., Carswell, H. V., Clarkson, A. N., Currie, G., Farr, T. D., Fowler, J. H., Good, M., Hainsworth, A. H., Hall, C., Horsburgh, K., Kalaria, R., Kehoe, P., Lawrence, C., Macleod, L., McColl, B. W., McNeilly, A., Miller, A. A., Miners, S., Mok, V., O'Sullivan, M., Platt, B., Sena, E. S., Sharp, M., Strangeward, P., Szymkowiak, S., Touyz, R. M., Trueman, R. C., White, C., McCabe, C., Work, L. M., and Quinn, T. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Journal of Cerebral Blood Flow and Metabolism
Publisher:SAGE Publications
ISSN:0271-678X
ISSN (Online):1559-7016
Published Online:09 March 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Journal of Cerebral Blood Flow and Metabolism 40(7):1402-1414
Publisher Policy:Reproduced under a Creative Commons licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
172199BHF 4 Year PhD Studentship Award (3rd intake 2015)Rhian TouyzBritish Heart Foundation (BHF)FS/15/64/32035Institute of Cardiovascular & Medical Sciences
172486Targeting mitochondrial stability as a new therapy for strokeLorraine WorkCunningham Trust (CUNNINGT)YL/JL/CU15007.0001Institute of Cardiovascular & Medical Sciences