Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia

Peirs, C., Dallel, R. and Todd, A. J. (2020) Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia. Journal of Neural Transmission, 127, pp. 505-525. (doi: 10.1007/s00702-020-02159-1) (PMID:32239353) (PMCID:PMC7148279)

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Abstract

The dorsal horns of the spinal cord and the trigeminal nuclei in the brainstem contain neuron populations that are critical to process sensory information. Neurons in these areas are highly heterogeneous in their morphology, molecular phenotype and intrinsic properties, making it difficult to identify functionally distinct cell populations, and to determine how these are engaged in pathophysiological conditions. There is a growing consensus concerning the classification of neuron populations, based on transcriptomic and transductomic analyses of the dorsal horn. These approaches have led to the discovery of several molecularly defined cell types that have been implicated in cutaneous mechanical allodynia, a highly prevalent and difficult-to-treat symptom of chronic pain, in which touch becomes painful. The main objective of this review is to provide a contemporary view of dorsal horn neuronal populations, and describe recent advances in our understanding of on how they participate in cutaneous mechanical allodynia.

Item Type:Articles
Additional Information:This research was also funded by Wellcome Trust (102645)
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Todd, Professor Andrew
Authors: Peirs, C., Dallel, R., and Todd, A. J.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Journal of Neural Transmission
Publisher:Springer
ISSN:0300-9564
ISSN (Online):1435-1463
Published Online:02 April 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Journal of Neural Transmission 127:505–525
Publisher Policy:Reproduced under a Creative Commons licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
302893Neuronal circuits for itch in the spinal dorsal hornAndrew ToddMedical Research Council (MRC)MR/S002987/1NP - Centre for Neuroscience
172232The role of NPY-containing inhibitory interneurons in spinal pain pathwaysAndrew ToddBiotechnology and Biological Sciences Research Council (BBSRC)BB/N006119/1NP - Centre for Neuroscience