Gurgone, D., McShane, L. , McSharry, C., Guzik, T. J. and Maffia, P. (2020) Cytokines at the interplay between asthma and atherosclerosis? Frontiers in Pharmacology, 11, 166. (doi: 10.3389/fphar.2020.00166)
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Publisher's URL: https://www.frontiersin.org/articles/10.3389/fphar.2020.00166/abstract
Abstract
Cardiovascular disease (CVD) is an important comorbidity in a number of chronic inflammatory diseases. However, evidence in highly prevalent respiratory disease such as asthma are still limited. Epidemiological and clinical data are not univocal in supporting the hypothesis that asthma and CVD are linked and the mechanisms of this relationship remain poorly defined. In this review, we explore the relationship between asthma and cardiovascular disease, with a specific focus on cytokine contribution to vascular dysfunction and atherosclerosis. This is important in the context of recent evidence linking broad inflammatory signalling to cardiovascular events. However inflammatory regulation in asthma is different to the one typically observed in atherosclerosis. We focus on the contribution of cytokine networks encompassing IL-4, IL-6, IL-9, IL-17A, IL-33 but also IFN-γ and TNF-α to vascular dysfunction in atherosclerosis. In doing so we highlight areas of unmet need and possible therapeutic implications.
| Item Type: | Articles |
|---|---|
| Additional Information: | Our work is supported by the British Heart Foundation (BHF) grants PG/12/81/29897, RE/13/5/30177, FS/16/55/32731, and PG/19/84/34771; the Engineering and Physical Sciences Research Council (EPSRC) grant EP/L014165/1; the European Commission Marie Skłodowska-Curie Individual Fellowships 661369 and the European Research Council (Project Identifier: 726318). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McShane, Ms Lucy and Maffia, Professor Pasquale and Gurgone, Dr Danila and Guzik, Professor Tomasz and McSharry, Dr Charles |
| Creator Roles: | Gurgone, D.Writing – original draft McShane, L.Writing – original draft McSharry, C.Writing – review and editing Guzik, T.Writing – review and editing Maffia, P.Writing – review and editing |
| Authors: | Gurgone, D., McShane, L., McSharry, C., Guzik, T. J., and Maffia, P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
| Journal Name: | Frontiers in Pharmacology |
| Publisher: | Frontiers Media |
| ISSN: | 1663-9812 |
| ISSN (Online): | 1663-9812 |
| Copyright Holders: | Copyright © 2020 Gurgone, McShane, McSharry, Guzik and Maffia |
| First Published: | First published in Frontiers in Pharmacology 11:166 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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