Cosmi, L. et al. (2008) Human interleukin 17–producing cells originate from a CD161+CD4+ T cell precursor. Journal of Experimental Medicine, 205(8), pp. 1903-1916. (doi: 10.1084/jem.20080397) (PMID:18663128) (PMCID:PMC2525581)
Full text not currently available from Enlighten.
Abstract
We demonstrate that CD161 is a highly up-regulated gene in human interleukin (IL) 17 T helper cell (Th17) clones and that all IL-17–producing cells are contained in the CD161+ fraction of CD4+ T cells present in the circulation or in inflamed tissues, although they are not CD1-restricted natural killer T cells. More importantly, we show that all IL-17–producing cells originate from CD161+ naive CD4+ T cells of umbilical cord blood, as well as of the postnatal thymus, in response to the combined activity of IL-1β and IL-23. These findings implicate CD161 as a novel surface marker for human Th17 cells and demonstrate the exclusive origin of these cells from a CD161+CD4+ T cell progenitor.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Rodolico, Dr Gabriella |
| Authors: | Cosmi, L., De Palma, R., Santarlasci, V., Maggi, L., Capone, M., Frosali, F., Rodolico, G., Querci, V., Abbate, G., Angeli, R., Berrino, L., Fambrini, M., Caproni, M., Tonelli, F., Lazzeri, E., Parronchi, P., Liotta, F., Maggi, E., Romagnani, S., and Annunziato, F. |
| College/School: | College of Social Sciences > School of Education |
| Journal Name: | Journal of Experimental Medicine |
| Publisher: | Rockefeller University Press |
| ISSN: | 0022-1007 |
| ISSN (Online): | 1540-9538 |
| Published Online: | 28 July 2008 |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric