Crosstalk between the M1 muscarinic acetylcholine receptor and the endocannabinoid system: A relevance for Alzheimer's disease?

Thompson, K. J. and Tobin, A. B. (2020) Crosstalk between the M1 muscarinic acetylcholine receptor and the endocannabinoid system: A relevance for Alzheimer's disease? Cellular Signalling, 70, 109545. (doi: 10.1016/j.cellsig.2020.109545) (PMID:31978506) (PMCID:PMC7184673)

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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder which accounts for 60-70% of the 50 million worldwide cases of dementia and is characterised by cognitive impairments, many of which have long been associated with dysfunction of the cholinergic system. Although the M muscarinic acetylcholine receptor (mAChR) is considered a promising drug target for AD, ligands targeting this receptor have so far been unsuccessful in clinical trials. As modulatory receptors to cholinergic transmission, the endocannabinoid system may be a promising drug target to allow fine tuning of the cholinergic system. Furthermore, disease-related changes have been found in the endocannabinoid system during AD progression and indeed targeting the endocannabinoid system at specific disease stages alleviates cognitive symptoms in numerous mouse models of AD. Here we review the role of the endocannabinoid system in AD, and its crosstalk with mAChRs as a potential drug target for cholinergic dysfunction. [Abstract copyright: Copyright © 2019. Published by Elsevier Inc.]

Item Type:Articles
Keywords:Acetylcholine, Alzheimer, Cannabinoid, Cholinergic, Crosstalk, Endocannabinoid.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Thompson, Ms Karen and Tobin, Andrew
Authors: Thompson, K. J., and Tobin, A. B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Cellular Signalling
Publisher:Elsevier
ISSN:0898-6568
ISSN (Online):1873-391
Published Online:21 January 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Cellular Signalling 70:109545
Publisher Policy:Reproduced under a Creative Commons licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
173304Collaborative Network to Define the Molecular Determinants of G Protein Coupled Receptor Clinical EfficacyAndrew TobinWellcome Trust (WELLCOTR)201529/Z/16/ZMCSB - Molecular Pharmacology