New insights into malaria pathogenesis

Moxon, C. A. , Gibbins, M. P. , McGuinness, D., Milner, D. A. and Marti, M. (2020) New insights into malaria pathogenesis. Annual Review of Pathology: Mechanisms of Disease, 15(1), pp. 315-343. (doi: 10.1146/annurev-pathmechdis-012419-032640) (PMID:31648610)

Abstract

Malaria remains a major public health threat in tropical and subtropical regions across the world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 deaths per year, predominantly in young children in sub-Saharan Africa. Therefore, it is imperative to understand why a subset of infected individuals develop severe syndromes and some of them die and what differentiates these cases from the majority that recovers. Here, we discuss progress made during the past decade in our understanding of malaria pathogenesis, focusing on the major human parasite Plasmodium falciparum.

• Item Type: Articles
• Additional Information: M.M. is supported by a Senior Investigator award from the Wellcome Trust, a consolidator award from the European Research Council, and a Wolfson Merit award from the Royal Society.
• Keywords: Pathology and forensic medicine.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Gibbins, Dr Matt and Marti, Professor Matthias and McGuinness, Dr Dagmara and Moxon, Dr Christopher
• Authors: Moxon, C. A., Gibbins, M. P., McGuinness, D., Milner, D. A., and Marti, M.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Annual Review of Pathology: Mechanisms of Disease
• Publisher: Annual Reviews
• ISSN: 1553-4014
• ISSN (Online): 1553-4014