Riddell, A. , McBride, M. , Braun, T., Nicklin, S. A. , Cameron, E. , Loughrey, C. M. and Martin, T. P. (2020) RUNX1: an emerging therapeutic target for cardiovascular disease. Cardiovascular Research, 116(8), pp. 1410-1423. (doi: 10.1093/cvr/cvaa034) (PMID:32154891) (PMCID:PMC7314639)
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Abstract
Runt-related transcription factor-1 (RUNX1), also known as acute myeloid leukaemia 1 protein (AML1), is a member of the core-binding factor family of transcription factors which modulate cell proliferation, differentiation, and survival in multiple systems. It is a master-regulator transcription factor, which has been implicated in diverse signalling pathways and cellular mechanisms during normal development and disease. RUNX1 is best characterized for its indispensable role for definitive haematopoiesis and its involvement in haematological malignancies. However, more recently RUNX1 has been identified as a key regulator of adverse cardiac remodelling following myocardial infarction. This review discusses the role RUNX1 plays in the heart and highlights its therapeutic potential as a target to limit the progression of adverse cardiac remodelling and heart failure.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Riddell, Dr Alexandra and Martin, Dr Tamara and McBride, Dr Martin and Loughrey, Professor Christopher and Nicklin, Professor Stuart and Cameron, Professor Ewan |
| Authors: | Riddell, A., McBride, M., Braun, T., Nicklin, S. A., Cameron, E., Loughrey, C. M., and Martin, T. P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Cardiovascular Research |
| Publisher: | Oxford University Press on behalf of the European Society of Cardiology |
| ISSN: | 0008-6363 |
| ISSN (Online): | 1755-3245 |
| Published Online: | 10 March 2020 |
| Copyright Holders: | Copyright © 2020 The Authors |
| First Published: | First published in Cardiovascular Research 116(8): 1410-1423 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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