RUNX1: an emerging therapeutic target for cardiovascular disease

Riddell, A., McBride, M. , Braun, T., Nicklin, S. A. , Cameron, E. , Loughrey, C. M. and Martin, T. P. (2020) RUNX1: an emerging therapeutic target for cardiovascular disease. Cardiovascular Research, 116(8), pp. 1410-1423. (doi: 10.1093/cvr/cvaa034) (PMID:32154891) (PMCID:PMC7314639)

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Abstract

Runt-related transcription factor-1 (RUNX1), also known as acute myeloid leukaemia 1 protein (AML1), is a member of the core-binding factor family of transcription factors which modulate cell proliferation, differentiation, and survival in multiple systems. It is a master-regulator transcription factor, which has been implicated in diverse signalling pathways and cellular mechanisms during normal development and disease. RUNX1 is best characterized for its indispensable role for definitive haematopoiesis and its involvement in haematological malignancies. However, more recently RUNX1 has been identified as a key regulator of adverse cardiac remodelling following myocardial infarction. This review discusses the role RUNX1 plays in the heart and highlights its therapeutic potential as a target to limit the progression of adverse cardiac remodelling and heart failure.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Riddell, Ms Alexandra and Martin, Dr Tamara and McBride, Dr Martin and Loughrey, Professor Christopher and Nicklin, Professor Stuart and Cameron, Professor Ewan
Authors: Riddell, A., McBride, M., Braun, T., Nicklin, S. A., Cameron, E., Loughrey, C. M., and Martin, T. P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Cardiovascular Research
Publisher:Oxford University Press on behalf of the European Society of Cardiology
ISSN:0008-6363
ISSN (Online):1755-3245
Published Online:10 March 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Cardiovascular Research 116(8): 1410-1423
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
301985Investigating the Therapeutic Potential of Runx1 for Myocardial InfarctionChristopher LoughreyBritish Heart Foundation (BHF)PG/18/9/33548CAMS - Cardiovascular Science