Plastic circuits: regulatory flexibility in fine tuning pathogen success

O'Boyle, N., Turner, N. C.A., Roe, A. J. and Connolly, J. P.R. (2020) Plastic circuits: regulatory flexibility in fine tuning pathogen success. Trends in Microbiology, 28(5), pp. 360-371. (doi: 10.1016/j.tim.2020.01.002) (PMID:32298614)

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Abstract

Bacterial pathogens employ diverse fitness and virulence mechanisms to gain an advantage in competitive niches. These lifestyle-specific traits require integration into the regulatory network of the cell and are often controlled by pre-existing transcription factors. In this review, we highlight recent advances that have been made in characterizing this regulatory flexibility in prominent members of the Enterobacteriaceae. We focus on the direct global interactions between transcription factors and their target genes in pathogenic Escherichia coli and Salmonella revealed using chromatin immunoprecipitation coupled with next-generation sequencing. Furthermore, the implications and advantages of such regulatory adaptations in benefiting distinct pathogenic lifestyles are discussed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Turner, Natasha and Connolly, Dr James and Roe, Professor Andrew and O'Boyle, Dr Nicky
Authors: O'Boyle, N., Turner, N. C.A., Roe, A. J., and Connolly, J. P.R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Trends in Microbiology
Publisher:Elsevier (Cell Press)
ISSN:0966-842X
ISSN (Online):1878-4380
Published Online:12 February 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Trends in Microbiology 28(5): 360-371
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
300280The Role of Dietary D-serine in Health and DiseaseAndrew RoeBiotechnology and Biological Sciences Research Council (BBSRC)BB/R006539/1III - Bacteriology