Charchar, F.J., Tomaszewski, M., Lacka, B., Zakrzewski, J., Zukowska-Szczechowska, E., Grzeszczak, W. and Dominiczak, A.F. (2004) Association of the human Y chromosome with cholesterol levels in the general population. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(2), pp. 308-312. (doi: 10.1161/01.ATV.0000113291.39267.0a)
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Abstract
Objective— Males are at higher risk of cardiovascular diseases than females. The aim of the study was to test whether the potential of the Y chromosome to affect cardiovascular risk could be attributed to its influence on lipids. Methods and Results— 1288 Polish men (1157 subjects from young healthy cohort and 131 individuals from middle-aged hypertensive population) were phenotyped for determinants of cardiovascular risk including BMI, blood pressures, lipids, and testosterone. Each subject was genotyped for the HindIII(+/−) polymorphism within the nonrecombining region of the Y chromosome. Men with the HindIII(−) variant exhibited significantly higher total cholesterol (TC) and low-density lipoprotein cholesterol (LDL) levels than subjects with the HindIII(+) genotype in both populations. The differences between the genotypes were 0.15 mmol/L (P=0.0107) and 0.45 mmol/L (P=0.0377) in TC and 0.15 mmol/L (P=0.0059) and 0.41 mmol/L (P=0.0432) in LDL among young apparently healthy men and middle-aged hypertensive men, respectively. The HindIII(+) was associated with a significant increase in blood pressure of the middle-aged men. Testosterone serum concentrations correlated positively with HDL-cholesterol levels, and this association was independent of the Y chromosome. Conclusions— The results indicate that a locus/loci on the Y chromosome may influence LDL levels, independent of testosterone levels.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Dominiczak, Professor Anna |
| Authors: | Charchar, F.J., Tomaszewski, M., Lacka, B., Zakrzewski, J., Zukowska-Szczechowska, E., Grzeszczak, W., and Dominiczak, A.F. |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Arteriosclerosis, Thrombosis, and Vascular Biology |
| Publisher: | American Heart Association |
| ISSN: | 1079-5642 |
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