Association of the human Y chromosome with cholesterol levels in the general population

Charchar, F.J., Tomaszewski, M., Lacka, B., Zakrzewski, J., Zukowska-Szczechowska, E., Grzeszczak, W. and Dominiczak, A.F. (2004) Association of the human Y chromosome with cholesterol levels in the general population. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(2), pp. 308-312. (doi:10.1161/01.ATV.0000113291.39267.0a)

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Abstract

Objective— Males are at higher risk of cardiovascular diseases than females. The aim of the study was to test whether the potential of the Y chromosome to affect cardiovascular risk could be attributed to its influence on lipids. Methods and Results— 1288 Polish men (1157 subjects from young healthy cohort and 131 individuals from middle-aged hypertensive population) were phenotyped for determinants of cardiovascular risk including BMI, blood pressures, lipids, and testosterone. Each subject was genotyped for the HindIII(+/−) polymorphism within the nonrecombining region of the Y chromosome. Men with the HindIII(−) variant exhibited significantly higher total cholesterol (TC) and low-density lipoprotein cholesterol (LDL) levels than subjects with the HindIII(+) genotype in both populations. The differences between the genotypes were 0.15 mmol/L (P=0.0107) and 0.45 mmol/L (P=0.0377) in TC and 0.15 mmol/L (P=0.0059) and 0.41 mmol/L (P=0.0432) in LDL among young apparently healthy men and middle-aged hypertensive men, respectively. The HindIII(+) was associated with a significant increase in blood pressure of the middle-aged men. Testosterone serum concentrations correlated positively with HDL-cholesterol levels, and this association was independent of the Y chromosome. Conclusions— The results indicate that a locus/loci on the Y chromosome may influence LDL levels, independent of testosterone levels.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dominiczak, Professor Anna
Authors: Charchar, F.J., Tomaszewski, M., Lacka, B., Zakrzewski, J., Zukowska-Szczechowska, E., Grzeszczak, W., and Dominiczak, A.F.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher:American Heart Association
ISSN:1079-5642

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