Examining the relationship between rheumatoid arthritis, multimorbidity and adverse health-related outcomes: a systematic review protocol

Canning, J., Siebert, S. , Jani, B. D. , Mair, F. S. and Nicholl, B. I. (2020) Examining the relationship between rheumatoid arthritis, multimorbidity and adverse health-related outcomes: a systematic review protocol. Journal of Comorbidity, 10, pp. 1-5. (doi: 10.1177/2235042X20906657)

[img]
Preview
Text
208941.pdf - Published Version
Available under License Creative Commons Attribution.

167kB

Abstract

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterised by articular inflammation and systemic complications. Multimorbidity (the presence of two or more long-term health conditions) is highly prevalent in people with RA but the effect of multimorbidity on mortality and other health-related outcomes is poorly understood. Objective: To determine what is known about the effect, if any, of multimorbidity on mortality and health-related outcomes in individuals with RA. Design: Systematic review of the literature. The following electronic medical databases will be searched: MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature, PsycINFO, The Cochrane Library and Scopus. Included studies will be quality appraised using the Quality in Prognostic Studies tool developed by the Cochrane Prognosis Methods Group. A narrative synthesis of findings will be undertaken and meta-analyses considered, if appropriate. This protocol adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols 2015 guidelines, ensuring the quality of the review. Conclusions: Understanding the influence of multimorbidity on mortality and other health-related outcomes in RA will provide an important basis of knowledge with the potential to improve future clinical management of RA. PROSPERO registration number: CRD42019137756.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Nicholl, Dr Barbara and Canning, Jordan and Jani, Dr Bhautesh and Siebert, Dr Stefan and Mair, Professor Frances
Authors: Canning, J., Siebert, S., Jani, B. D., Mair, F. S., and Nicholl, B. I.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Comorbidity
Publisher:SAGE
ISSN:2235-042X
ISSN (Online):2235-042X
Published Online:16 March 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Journal of Comorbidity 10:1-5
Publisher Policy:Reproduced under a Creative Commons licence

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
304005MRC Precision Medicine Training GrantMorven BarlassMedical Research Council (MRC)MR/N013166/1-LGH/MS/MED25CAMS - Cardiovascular Science