Leucocyte expression of the chemokine scavenger D6

Graham, G.J. and McKimmie, C.S. (2006) Leucocyte expression of the chemokine scavenger D6. Biochemical Society Transactions, 34(6), pp. 1002-1004. (doi: 10.1042/BST0341002)

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Publisher's URL: http://dx.doi.org/10.1042/BST0341002

Abstract

Selective sequestration of inflammatory chemokines is critical for the successful resolution of inflammatory responses in vivo. D6 is an atypical chemokine receptor that scavenges inflammatory chemokines and is pivotal in resolving models of chemokine-driven cutaneous inflammation. We provide evidence that expression of D6 is not limited to the lymphatic endothelium at sites of inflammation as previously believed. Instead we postulate that D6 expression in leucocytes may have a significant impact upon chemokine bioavailability during the resolution phase of inflammation. D6 expressed on the lymphatic endothelia may instead have complementary roles in preventing inappropriate leucocyte migration to the lymph node by keeping the endothelium free from inflammatory chemokines.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McKimmie, Dr Clive and Graham, Professor Gerard
Authors: Graham, G.J., and McKimmie, C.S.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Biochemical Society Transactions
ISSN:0300-5127
ISSN (Online):1470-8752

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