Jamieson, T., Cook, D. N., Nibbs, R. J.B. , Rot, A., Nixon, C., Mclean, P., Alcami, A., Lira, S. A., Wiekowski, M. and Graham, G. J. (2005) The chemokine receptor D6 limits the inflammatory response in vivo. Nature Immunology, 6, pp. 403-411. (doi: 10.1038/ni1182)
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Abstract
How the inflammatory response is initiated has been well defined but relatively little is known about how such responses are resolved. Here we show that the D6 chemokine receptor is involved in the post-inflammatory clearance of beta-chemokines from cutaneous sites. After induction of inflammation by phorbol esters, wild-type mice showed a transient inflammatory response. However, in D6-deficient mice, an excess concentration of residual chemokines caused a notable inflammatory pathology with similarities to human psoriasis. These results suggest that D6 is involved in the resolution of the cutaneous inflammatory response.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Nixon, Mr Colin and Nibbs, Professor Rob and Graham, Professor Gerard |
| Authors: | Jamieson, T., Cook, D. N., Nibbs, R. J.B., Rot, A., Nixon, C., Mclean, P., Alcami, A., Lira, S. A., Wiekowski, M., and Graham, G. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Nature Immunology |
| Publisher: | Nature Publishing Group |
| ISSN: | 1529-2908 |
| ISSN (Online): | 1529-2916 |
| Published Online: | 06 March 2005 |
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