The chemokine receptor D6 limits the inflammatory response in vivo

Jamieson, T., Cook, D. N., Nibbs, R. J.B. , Rot, A., Nixon, C., Mclean, P., Alcami, A., Lira, S. A., Wiekowski, M. and Graham, G. J. (2005) The chemokine receptor D6 limits the inflammatory response in vivo. Nature Immunology, 6, pp. 403-411. (doi: 10.1038/ni1182)

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Abstract

How the inflammatory response is initiated has been well defined but relatively little is known about how such responses are resolved. Here we show that the D6 chemokine receptor is involved in the post-inflammatory clearance of beta-chemokines from cutaneous sites. After induction of inflammation by phorbol esters, wild-type mice showed a transient inflammatory response. However, in D6-deficient mice, an excess concentration of residual chemokines caused a notable inflammatory pathology with similarities to human psoriasis. These results suggest that D6 is involved in the resolution of the cutaneous inflammatory response.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Nibbs, Professor Rob and Nixon, Mr Colin and Graham, Professor Gerard
Authors: Jamieson, T., Cook, D. N., Nibbs, R. J.B., Rot, A., Nixon, C., Mclean, P., Alcami, A., Lira, S. A., Wiekowski, M., and Graham, G. J.
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Nature Immunology
Publisher:Nature Publishing Group
ISSN:1529-2908
ISSN (Online):1529-2916
Published Online:06 March 2005

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