Derakhshan, M., El Omar, E., Oien, K., Gillen, D., Fyfe, V., Crabtree, J. and McColl, K. (2006) Gastric histology, serological markers and age as predictors of gastric acid secretion in patients infected with Helicobacter pylori. Journal of Clinical Pathology, 59(12), pp. 1293-1299. (doi: 10.1136/jcp.2005.036111)
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Abstract
Background: Acid secretion is intimately associated with most upper gastrointestinal diseases. Helicobacter pylori infection is a major environmental factor modifying acid secretion. Aim: To study the association between the pattern of H pylori gastritis and gastric secretory function in a large number of subjects without specific upper gastrointestinal disease. Methods and materials: Maximal acid output (MAO) was measured in 255 patients with dyspepsia showing normal endoscopy. Activity and severity of gastritis, atrophy and H pylori infection were assessed in body and antral biopsies. The correlations of histological parameters as well as age, sex, height, weight, smoking, serum gastrin, pepsinogen I and II, and their ratio with MAO were determined. Multiple linear regression was used to show the best possible predictors of MAO. Results: Negative relationships: Body atrophy and body-combined (active and chronic) inflammatory scores showed a potent inverse correlation with MAO (correlation coefficients (CC) 0.59 and 0.50, respectively). Body: antral chronic gastritis ratio and body: antral combined inflammation ratio ( both with CC = 0.49) and age (CC = 0.44) were also inversely correlated with MAO. Intestinal metaplasia at both antral and body sites had negative relationships with acid output with CC=0.23 and 0.20, respectively. Positive relationships: Serum pepsinogen I, body H pylori density: combined inflammation ratio and pepsinogen I:II ratio with CC of 0.38, 0.38 and 0.30, respectively, correlated with MAO. The H pylori density: combined inflammation of both antrum and body positively correlated with MAO (CC = 0.29 and 0.38, respectively). Male sex and patient height also positively correlated with acid output. Modelling showed that body combined inflammatory score, body atrophy, age and serum pepsinogen I are independent predictors of acid output (R-2 = 0.62).
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McColl, Professor Kenneth and Oien, Professor Karin and Derakhshan, Professor Mohammad |
| Authors: | Derakhshan, M., El Omar, E., Oien, K., Gillen, D., Fyfe, V., Crabtree, J., and McColl, K. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Journal of Clinical Pathology |
| Publisher: | BMJ Publishing Group Ltd. |
| ISSN: | 0021-9746 |
| Published Online: | 27 April 2006 |
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