Lucas-Herald, A. K. , Mason, E., Beaumont, P., Mason, A., Shaikh, M. G., Wong, S. C. and Ahmed, S. F. (2018) Single-centre experience of testosterone therapy for boys with hypogonadism. Hormone Research in Paediatrics, 90(2), pp. 123-127. (doi: 10.1159/000490738) (PMID:30021202)
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Abstract
Background: Hypogonadism in boys is one of the commonest conditions encountered in paediatric endocrinology. Aims: To study variations in management in a contemporary group of boys at a single specialist centre. Methods: Retrospective review of case records of all boys treated with testosterone at a tertiary endocrine service from 2012 to 2017. Results: Of the 358 boys reviewed for hypogonadism, 46 (13%) were initiated on testosterone therapy at a median age (range) of 14.2 years (12.1, 17.7). Indications for therapy included a functional delay of puberty that was constitutional in 17 (37%) or related to chronic disease in 10 (22%) or organic hypogonadism due to primary gonadal failure in 7 (15%), multiple pituitary hormone deficiency in 6 (13%), and isolated hypogonadotropic hypogonadism in 6 (13%). Of the 46 boys, 40 (89%) were started on intramuscular testosterone, 4 (9%) on oral testosterone, and 1 (2%) on transdermal gel. Of the 19 boys (40%) with organic hypogonadism requiring long-term therapy, 12 (63%) had assessment of liver function, 6 (32%) had a haematocrit, and 2 (11%) had a DXA scan in the year of commencing treatment. Conclusions: Testosterone therapy is administered in about 13% of boys reviewed for hypogonadism and its monitoring requires standardisation.
Item Type: | Articles |
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Additional Information: | A.K.L.-H. is supported by a BHF Centre of Excellence Clinical Research Training Fellowship award (RE/13/5/30177). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Shaikh, Dr Mohammed Guftar and Ahmed, Professor Syed Faisal and Wong, Dr Jarod and Mason, Dr Avril and Lucas-Herald, Dr Angela |
Authors: | Lucas-Herald, A. K., Mason, E., Beaumont, P., Mason, A., Shaikh, M. G., Wong, S. C., and Ahmed, S. F. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Hormone Research in Paediatrics |
Publisher: | Karger Publishers |
ISSN: | 1663-2818 |
ISSN (Online): | 1663-2826 |
Published Online: | 18 July 2018 |
Copyright Holders: | Copyright © 2018 S. Karger AG, Basel |
First Published: | First published in Hormone Research in Paediatrics 90(2):123-127 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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