Single-centre experience of testosterone therapy for boys with hypogonadism

Lucas-Herald, A. K. , Mason, E., Beaumont, P., Mason, A., Shaikh, M. G., Wong, S. C. and Ahmed, S. F. (2018) Single-centre experience of testosterone therapy for boys with hypogonadism. Hormone Research in Paediatrics, 90(2), pp. 123-127. (doi: 10.1159/000490738) (PMID:30021202)

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Background: Hypogonadism in boys is one of the commonest conditions encountered in paediatric endocrinology. Aims: To study variations in management in a contemporary group of boys at a single specialist centre. Methods: Retrospective review of case records of all boys treated with testosterone at a tertiary endocrine service from 2012 to 2017. Results: Of the 358 boys reviewed for hypogonadism, 46 (13%) were initiated on testosterone therapy at a median age (range) of 14.2 years (12.1, 17.7). Indications for therapy included a functional delay of puberty that was constitutional in 17 (37%) or related to chronic disease in 10 (22%) or organic hypogonadism due to primary gonadal failure in 7 (15%), multiple pituitary hormone deficiency in 6 (13%), and isolated hypogonadotropic hypogonadism in 6 (13%). Of the 46 boys, 40 (89%) were started on intramuscular testosterone, 4 (9%) on oral testosterone, and 1 (2%) on transdermal gel. Of the 19 boys (40%) with organic hypogonadism re­quiring long-term therapy, 12 (63%) had assessment of liver function, 6 (32%) had a haematocrit, and 2 (11%) had a DXA scan in the year of commencing treatment. Conclusions: Testosterone therapy is administered in about 13% of boys reviewed for hypogonadism and its monitoring requires standardisation.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Shaikh, Dr Mohammed Guftar and Ahmed, Professor Syed Faisal and Wong, Dr Jarod and Mason, Dr Avril and Lucas-Herald, Dr Angela
Authors: Lucas-Herald, A. K., Mason, E., Beaumont, P., Mason, A., Shaikh, M. G., Wong, S. C., and Ahmed, S. F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Hormone Research in Paediatrics
Publisher:Karger Publishers
ISSN (Online):1663-2826
Published Online:18 July 2018
Copyright Holders:Copyright © 2018 S. Karger AG, Basel
First Published:First published in Hormone Research in Paediatrics 90(2):123-127
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190814BHF centre of excellenceRhian TouyzBritish Heart Foundation (BHF)RE/13/5/30177Institute of Cardiovascular & Medical Sciences