Effects of recombinant human growth hormone in children with Crohn’s disease on the muscle-bone Unit: a preliminary study

ALTOWATI, M. A., Shepherd, S., McGrogan, P., Russell, R. K., Ahmed, S. F. and Wong, S. C. (2018) Effects of recombinant human growth hormone in children with Crohn’s disease on the muscle-bone Unit: a preliminary study. Hormone Research in Paediatrics, 90(2), pp. 128-131. (doi:10.1159/000492398) (PMID:30149380)

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Abstract

Background/Aims: There is limited information on the impact of recombinant human growth hormone (rhGH) on the muscle-bone unit in children with Crohn’s disease (CD). In this pilot study, we report on the effects of rhGH on bone formation, dual-energy X-ray absorptiometry (DXA) total body (TB) bone mineral density adjusted for height and lumbar spine (LS) bone mineral apparent density (BMAD), and body composition. Methods: Prospective study of 8 children with CD (6 male), aged 14.8 years (9.0–16.4), who received rhGH for 24 months. Serum procollagen type 1 N-terminal propeptide (P1NP) was measured at baseline and at 6 months. DXA was performed every 6 months. Results: Six months of rhGH led to improvement in P1NP SDS adjusted for bone age from –3.6 (–7.9 to –0.9) to –2.4 (–3.7 to 0.4) (p = 0.01). At baseline, reduction in LS-BMAD and TB lean mass SDS was observed being –1.2 (–3.6 to 0.8) (p = 0.01 vs. zero) and –0.8 (–2.4 to 3.0) (p = 0.11 vs. zero), respectively. No significant changes were seen in DXA bone and muscle parameters over the 24 months. Conclusion: Twenty-four months of therapy with rhGH in CD did not lead to an improvement in DXA BMD and lean mass, despite improvement in P1NP and linear growth.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ahmed, Professor Syed Faisal and Shepherd, Dr Sheila and ALTOWATI, Mabrouka
Authors: ALTOWATI, M. A., Shepherd, S., McGrogan, P., Russell, R. K., Ahmed, S. F., and Wong, S. C.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Hormone Research in Paediatrics
Publisher:Karger Publishers
ISSN:1663-2818
ISSN (Online):1663-2826
Published Online:27 August 2018

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