The emerging role of GABAB receptors as regulators of network dynamics: fast actions from a 'slow' receptor?

Craig, M. T. and McBain, C. J. (2014) The emerging role of GABAB receptors as regulators of network dynamics: fast actions from a 'slow' receptor? Current Opinion in Neurobiology, 26, pp. 15-21. (doi: 10.1016/j.conb.2013.10.002) (PMID:24650499) (PMCID:PMC4024344)

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Abstract

Convention holds that ionotropic receptors mediate fast neurotransmission and that ‘slow’ G-protein coupled metabotropic receptors have a secondary, modulatory role in the control of neuronal networks. Here, we discuss recent evidence showing that activation of metabotropic GABAB receptors in cortical layer 1 can powerfully inhibit principal cell activity and that their activation can rapidly halt ongoing network activity. Inputs from both within and outwith the cortex converge upon layer 1 where they target various populations of interneurons, including neurogliaform cells. We argue that neurogliaform cells are the main effector of a powerful inhibitory circuit that, acting through GABAB receptors, can be differentially recruited by long-range connections to serve in roles as diverse as conscious perception and memory consolidation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Craig, Dr Mick
Authors: Craig, M. T., and McBain, C. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Current Opinion in Neurobiology
Publisher:Elsevier
ISSN:0959-4388
ISSN (Online):1873-6882
Published Online:19 November 2013

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