Pelkey, K. A., Chittajallu, R., Craig, M. T. , Tricoire, L., Wester, J. C. and McBain, C. J. (2017) Hippocampal GABAergic inhibitory interneurons. Physiological Reviews, 97(4), pp. 1619-1747. (doi: 10.1152/physrev.00007.2017) (PMID:28954853) (PMCID:PMC6151493)
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Abstract
In the hippocampus GABAergic local circuit inhibitory interneurons represent only ~10–15% of the total neuronal population; however, their remarkable anatomical and physiological diversity allows them to regulate virtually all aspects of cellular and circuit function. Here we provide an overview of the current state of the field of interneuron research, focusing largely on the hippocampus. We discuss recent advances related to the various cell types, including their development and maturation, expression of subtype-specific voltage- and ligand-gated channels, and their roles in network oscillations. We also discuss recent technological advances and approaches that have permitted high-resolution, subtype-specific examination of their roles in numerous neural circuit disorders and the emerging therapeutic strategies to ameliorate such pathophysiological conditions. The ultimate goal of this review is not only to provide a touchstone for the current state of the field, but to help pave the way for future research by highlighting where gaps in our knowledge exist and how a complete appreciation of their roles will aid in future therapeutic strategies.
| Item Type: | Articles |
|---|---|
| Additional Information: | The work was supported by a National Institute of Child Health and Human Development Intramural Research Award (to C. J. McBain). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Craig, Dr Mick |
| Authors: | Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., and McBain, C. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
| Journal Name: | Physiological Reviews |
| Publisher: | American Physiological Society |
| ISSN: | 0031-9333 |
| ISSN (Online): | 1522-1210 |
| Published Online: | 27 September 2017 |
| Copyright Holders: | Copyright © 2017 American Physiological Society |
| First Published: | First published in Physiological Reviews 97(4): 1619-1747 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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