Association between extra-genital congenital anomalies and hypospadias outcome

Al-Juraibah, F., Lucas-Herald, A. , Nixon, R., Toka, C., Wang, C., Flett, M., O'Toole, S. and Ahmed, S. F. (2019) Association between extra-genital congenital anomalies and hypospadias outcome. Sexual Development, 13(2), pp. 67-73. (doi: 10.1159/000497260) (PMID:30913557)

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Abstract

Extra-genital congenital anomalies are often present in cases of hypospadias, but it is unclear whether they have an association with the outcome of hypospadias surgery. The aim of this study was to review all hypospadias cases that had surgery between 2009 and 2015 at a single centre and identify clinical determinants of the surgical outcome. An extra-genital congenital anomaly was reported in 139 (22%) boys and 62 (10%) had more than 1 anomaly. Of the 626 boys, 54 (9%), including 44 with proximal hypospadias, had endocrine as well as limited genetic evaluation. Of these, 10 (19%) had a biochemical evidence of hypogonadism and 5 (9%) had a molecular genetic abnormality. At least 1 complication was reported in 167 (27%) patients, with 20% of complications (most frequently fistula) occurring after 2 years of surgery. The severity of hypospadias and the existence of other anomalies were clinical factors that were independently associated with an increased risk of complications (p < 0.001). In conclusion, complications following surgery are more likely in those cases that are proximal or who have additional extra-genital anomalies. To understand the biological basis of these complications, there is a greater need to understand the aetiology of such cases.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ahmed, Professor Syed Faisal and Lucas-Herald, Dr Angela
Authors: Al-Juraibah, F., Lucas-Herald, A., Nixon, R., Toka, C., Wang, C., Flett, M., O'Toole, S., and Ahmed, S. F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Sexual Development
Publisher:Karger
ISSN:1661-5425
ISSN (Online):1661-5433
Published Online:26 March 2019
Copyright Holders:Copyright © 2019 S. Karger AG, Basel
First Published:First published in Sexual Development 13(2):67-73
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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