Mental health in UK Biobank – development, implementation and results from an online questionnaire completed by 157 366 participants: a reanalysis

Davis, K. A.S. et al. (2020) Mental health in UK Biobank – development, implementation and results from an online questionnaire completed by 157 366 participants: a reanalysis. BJPsych Open, 6(2), e18. (doi: 10.1192/bjo.2019.100) (PMID:32026800) (PMCID:PMC7176892)

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Abstract

Background: UK Biobank is a well-characterised cohort of over 500 000 participants including genetics, environmental data and imaging. An online mental health questionnaire was designed for UK Biobank participants to expand its potential. Aims: Describe the development, implementation and results of this questionnaire. Method: An expert working group designed the questionnaire, using established measures where possible, and consulting a patient group. Operational criteria were agreed for defining likely disorder and risk states, including lifetime depression, mania/hypomania, generalised anxiety disorder, unusual experiences and self-harm, and current post-traumatic stress and hazardous/harmful alcohol use. Results: A total of 157 366 completed online questionnaires were available by August 2017. Participants were aged 45–82 (53% were ≥65 years) and 57% women. Comparison of self-reported diagnosed mental disorder with a contemporary study shows a similar prevalence, despite respondents being of higher average socioeconomic status. Lifetime depression was a common finding, with 24% (37 434) of participants meeting criteria and current hazardous/harmful alcohol use criteria were met by 21% (32 602), whereas other criteria were met by less than 8% of the participants. There was extensive comorbidity among the syndromes. Mental disorders were associated with a high neuroticism score, adverse life events and long-term illness; addiction and bipolar affective disorder in particular were associated with measures of deprivation. Conclusions: The UK Biobank questionnaire represents a very large mental health survey in itself, and the results presented here show high face validity, although caution is needed because of selection bias. Built into UK Biobank, these data intersect with other health data to offer unparalleled potential for crosscutting biomedical research involving mental health.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Smith, Professor Daniel and Cullen, Dr Breda and Graham, Dr Nicholas and Pearsall, Dr Robert and Ward, Dr Joey
Authors: Davis, K. A.S., Coleman, J. R.I., Adams, M., Allen, N., Breen, G., Cullen, B., Dickens, C., Fox, E., Graham, N., Holliday, J., Howard, L. M., John, A., Lee, W., McCabe, R., McIntosh, A., Pearsall, R., Smith, D. J., Sudlow, C., Ward, J., Zammit, S., and Hotopf, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
Journal Name:BJPsych Open
Publisher:Royal College of Psychiatrists
ISSN:2056-4724
ISSN (Online):2056-4724
Published Online:06 February 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in BJPsych Open 6(2): e18
Publisher Policy:Reproduced under a Creative Commons License
Data DOI:10.17632/kv677c2th4.3

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
170567Cognitive outcomes in people with behavioural and brain disorders within UK BiobankBreda CullenChief Scientist Office (CSO)DTF/14/03HW - Mental Health and Wellbeing
173096Investigating comorbidity between hypertension and bipolar disorder to identify new and repurposed medications for bipolar disorderDaniel SmithLister Institute of Preventive Medicine (LISTININ)Research Prize 2016HW - Mental Health and Wellbeing