Testosterone therapy in adolescent boys: the need for a structured approach

Stancampiano, M. R., Lucas-Herald, A. K. , Russo, G., Rogol, A. D. and Ahmed, S. F. (2019) Testosterone therapy in adolescent boys: the need for a structured approach. Hormone Research in Paediatrics, 2019(92), pp. 215-228. (doi: 10.1159/000504670) (PMID:31851967)

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In adolescents, testosterone may have several effects including promotion of secondary sexual characteristics and pubertal growth, attainment of optimal muscle mass and peak bone mass, optimization of the metabolic profile, and psychosocial maturation and well-being. Testosterone therapy is a cornerstone of the management of hypogonadism in boys. Since the initial report of the chemical synthesis of testosterone, several formulations have continued to develop, and although many of these have been used in boys, none of them have been studied in detail in this age group. Given the wide ranging effects of testosterone, the level of evidence for their effects in boys and the heterogeneity of conditions that lead to early-onset hypogonadism, a standardized protocol for monitoring testosterone replacement in this age group is needed. Key Messages: In this review, we focus on the perceived benefits of androgen replacement in boys affected by pubertal delay and highlight the need to improve the health monitoring of boys who receive androgen replacement therapy, proposing different approaches based on the underlying pathophysiology.

Item Type:Articles
Keywords:Adolescent, boys, hypogonadism, pubertal delay, testosterone.
Glasgow Author(s) Enlighten ID:Ahmed, Professor Syed Faisal and Stancampiano, Dr Marianna and Lucas-Herald, Dr Angela
Authors: Stancampiano, M. R., Lucas-Herald, A. K., Russo, G., Rogol, A. D., and Ahmed, S. F.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Hormone Research in Paediatrics
ISSN (Online):1663-2826

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