Synovial tissue analysis in clinical trials

Baeten, D. et al. (2005) Synovial tissue analysis in clinical trials. Journal of Rheumatology, 32, pp. 2481-2484. (PMID:16331792)

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Publisher's URL: http://www.jrheum.org/content/32/12/2481.abstract

Abstract

Synovial tissue analysis has considerable potential for future randomized controlled trials (RCT). The synovial membrane is the target tissue in treatment strategies of rheumatoid arthritis and other arthropathies. Effective modulation of synovitis is critical when attempting to control symptoms and signs, to prevent joint damage, and to maintain function. In RCT, the systematic evaluation of changes in synovial tissue after commencing treatment enables identification of an early therapeutic effect, using relatively small numbers of patients. This special interest group is working on establishing the evidence to have this endpoint meet the OMERACT filter criteria.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain
Authors: Baeten, D., Bresnihan, B., Firestein, G., Fitzgerald, O., Gerlag, D., Haringman, J., McInnes, I., Reece, R., Smith, M., Tak, P., Ulfgren, A., and Veale, D.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Rheumatology
Publisher:Journal of Rheumatology
ISSN:0315-162X

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