Physical activity, dietary intake and metabolic risk factors in non-diabetic daughters of patients with type II diabetes

Higgins, S., Gill, J.M.R. , Janilionyte, R., Caslake, M.J. and Malkova, D. (2005) Physical activity, dietary intake and metabolic risk factors in non-diabetic daughters of patients with type II diabetes. Preventive Medicine, 40(2), pp. 145-151. (doi:10.1016/j.ypmed.2004.05.004)

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Abstract

Background. It has been reported that the offspring of patients with type II diabetes have an adverse metabolic risk profile. This study aimed to investigate the impact of habitual physical activity and diet on metabolic risk factors in the daughters of patients with type II diabetes and control subjects.<p></p> Methods. Thirty-nine offspring and 39 age- and sex-matched controls completed physical activity and food intake diaries, during the week preceding a fasting blood sample.<p></p> Results. The offspring had higher body mass index, percentage body fat, and waist circumference than the control subjects (all P < 0.01). Fasting glucose and insulin, and insulin sensitivity estimated by the homeostasis model assessment (HOMAIR) method, were also higher in the offspring group (all P < 0.01). Daily energy expenditure was lower (P < 0.0001) in the offspring than control group. Dietary profile was not different between the groups. Daily energy expenditure was significantly correlated with waist circumference, fasting insulin, and HOMAIR (all P < 0.05) in offspring but not controls.<p></p> Conclusions. Offspring had a less favourable physical and metabolic profile and were less physically active than control subjects. In offspring, central adiposity and metabolic risk factors were influenced by habitual physical activity to a greater degree than in control subjects.<p></p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Malkova, Dr Dale and Gill, Professor Jason and Caslake, Professor Muriel
Authors: Higgins, S., Gill, J.M.R., Janilionyte, R., Caslake, M.J., and Malkova, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Preventive Medicine
ISSN:0091-7435
ISSN (Online):1096-0260
Published Online:19 July 2004

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