Fabrication of micropillar substrates using replicas of alpha-particle irradiated and chemically etched PADC films

Ng, C.K.M., Chong, E.Y.W., Roy, V.A.L. , Cheung, K.M.C., Yeung, K.W.K. and Yu, K.N. (2012) Fabrication of micropillar substrates using replicas of alpha-particle irradiated and chemically etched PADC films. Applied Radiation and Isotopes, 70(7), pp. 1432-1435. (doi: 10.1016/j.apradiso.2011.11.019)

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Abstract

We proposed a simple method to fabricate micropillar substrates. Polyallyldiglycol carbonate (PADC) films were irradiated by alpha particles and then chemically etched to form a cast with micron-scale spherical pores. A polydimethylsiloxane (PDMS) replica of this PADC film gave a micropillar substrate with micron-scale spherical pillars. HeLa cells cultured on such a micropillar substrate had significantly larger percentage of cells entering S-phase, attached cell numbers and cell spreading areas.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vellaisamy, Professor Roy
Authors: Ng, C.K.M., Chong, E.Y.W., Roy, V.A.L., Cheung, K.M.C., Yeung, K.W.K., and Yu, K.N.
College/School:College of Science and Engineering > School of Engineering
Journal Name:Applied Radiation and Isotopes
Publisher:Elsevier
ISSN:0969-8043
ISSN (Online):1872-9800
Published Online:18 November 2011

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