Theoretical framework of radiation force in surface acoustic waves for modulated particle sorting

Bernassau, A. L., Riehle, M. O. , Desmulliez, M. P.Y., Andrade, M. A.B. and Simon, G. (2019) Theoretical framework of radiation force in surface acoustic waves for modulated particle sorting. Periodica Polytechnica Electrical Engineering and Computer Science, 63(2), pp. 77-84. (doi: 10.3311/PPee.13454)

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Abstract

Sorting specific target entities from sample mixtures is commonly used in many macroscale laboratory processing, such as disease diagnosis or treatment. Downscaling of sorting systems enables less laboratory space and fewer quantities of sample and reagent. Such lab-on-a-chip devices can perform separation functions using passive or active sorting methods. Such a method, acoustic sorting, when used in microfluidics, offers contactless, label-free, non-invasive manipulation of target cells or particles and is therefore the topic of active current research. Our phase-modulated sorting technique complements traditional time-of-flight techniques and offers higher sensitivity separation using a periodic signal. By cycling of this periodic signal, the target entities are gradually displaced compared to the background debris, thereby achieving sorting. In this paper, we extend the knowledge on phase-modulated sorting techniques. Firstly, using numerical simulations, we confirm the sorting role of our proposed primary acoustic radiation force within surface wave devices. Secondly, a threefold agreement between analytical, numerical and experimental sorting trajectories is presented.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Riehle, Dr Mathis
Authors: Bernassau, A. L., Riehle, M. O., Desmulliez, M. P.Y., Andrade, M. A.B., and Simon, G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Periodica Polytechnica Electrical Engineering and Computer Science
Publisher:Budapest University of Technology and Economics
ISSN:2064-5260
ISSN (Online):2064-5279
Published Online:28 March 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Periodica Polytechnica Electrical Engineering and Computer Science 63(2):77-84
Publisher Policy:Reproduced under a Creative Commons License

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